接受人生长激素治疗的患者体内出现的抗动物生长激素抗体：其特异性及对生长速度的影响。

Antibodies against animal growth hormones appearing in patients treated with human growth hormone: their specificities and influence on growth velocity.

作者信息

Pérez A R, Peña C, Poskus E, Paladini A C, Domené H M, Martínez A S, Heinrich J J

出版信息

Acta Endocrinol (Copenh). 1985 Sep;110(1):24-31. doi: 10.1530/acta.0.1100024.

DOI:10.1530/acta.0.1100024

Abstract

The appearance of anti-human growth hormone (hGH) and anti-non-hGHs antibodies in 27 patients with idiopathic hypopituitarism, treated for periods of 6-18 months with three different preparations of hGH, was investigated. The preparations induced antibodies to GH in 21 out of the 27 patients: 10 patients produced exclusively an anti-non-hGH response, whereas 11 generated both anti-non-hGH and anti-hGH antibodies. The levels of antibodies against hGH had low correlation with decreased growth velocity, whereas those for the antibodies against non-hGHs did not correlate with decreased growth velocity.

摘要

对27例特发性垂体功能减退患者进行了研究，这些患者使用三种不同的人生长激素（hGH）制剂治疗6至18个月，观察抗hGH和抗非hGH抗体的出现情况。在27例患者中，有21例患者的制剂诱导产生了抗GH抗体：10例患者仅产生抗非hGH反应，而11例患者同时产生抗非hGH和抗hGH抗体。抗hGH抗体水平与生长速度降低的相关性较低，而抗非hGH抗体水平与生长速度降低无相关性。