Nielsen N V
Acta Ophthalmol (Copenh). 1985 Jun;63(3):311-4. doi: 10.1111/j.1755-3768.1985.tb06811.x.
In 17 insulin dependent diabetics with an apparently normal ophthalmoscopy at the entry of the study, there was a) an individual variation regarding observed fundus elements and b) an intraindividual variation during the observation time of one year, as evident from fundus fluorescein angiography, colour photography and red free filter photography. The examinations were performed on one eye in each subject three times within one year. Hyperfluorescent elements--varying in number from 1 to 5--were found totally in 14 eyes (= 82%). In 6 eyes (= 35%) the number of minute hyperfluorescent fundus elements varied during one year. Hypofluorescent elements were present in 14 eyes (12 eyes with indistinctly and and 2 with distinctly outlined elements) and showed no variation during one year. Eleven eyes (65%) had minute elements--varying in number from 1 to 7--in the colour and red free filter photographs not visualized in the angiograms. After one year 8 red elements were found in 5 eyes, 6 with and 2 without fluorescence. The remaining fluorescent and non-fluorescent elements, constantly present, appeared as minute yellowish spots (n = 37).
在17例胰岛素依赖型糖尿病患者中，研究开始时眼底镜检查结果明显正常，a）观察到的眼底成分存在个体差异，b）从眼底荧光血管造影、彩色摄影和无赤滤光片摄影可以看出，在一年的观察期内存在个体内差异。在一年内，对每个受试者的一只眼睛进行了三次检查。共在14只眼睛（=82%）中发现了数量从1到5不等的高荧光成分。在6只眼睛（=35%）中，微小高荧光眼底成分的数量在一年内有所变化。14只眼睛中存在低荧光成分（12只眼睛的成分不清晰，2只眼睛的成分轮廓清晰），且在一年内没有变化。11只眼睛（65%）在彩色和无赤滤光片照片中有数量从1到7不等的微小成分，而在血管造影中未显示。一年后，在5只眼睛中发现了8个红色成分，其中6个有荧光，2个没有荧光。其余持续存在的荧光和非荧光成分表现为微小的淡黄色斑点（n = 37）。
