Bushi Ganesh, Khatib Mahalaqua Nazli, S Renuka Jyothi, Kaur Irwanjot, Sharma Abhishek, Iqbal Suhaib, Kumar M Ravi, Chauhan Ashish Singh, Vishwakarma Teena, Malik Praveen, Zahiruddin Quazi Syed, Singh Mahendra Pratap, Shabil Muhammed, Mehta Rachana, Sah Sanjit, Albayat Hawra, Sulaiman Tarek, Al Bshabshe Ali, Al Kaabi Nawal A, Alrasheed Hayam A, Alfaresi Mubarak, Sabour Amal A, Alamri Eman, Al-Subaie Maha F, Rabaan Ali A
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
Division of Evidence Synthessis, Global Consortium of Public Health and Research, Datta Meghe Institute of Higher Education, Wardha, Maharashtra, India.
Immun Inflamm Dis. 2025 May;13(5):e70205. doi: 10.1002/iid3.70205.
Malaria is a life-threatening disease caused by Plasmodium parasites, transmitted through the bites of infected female Anopheles mosquitoes. It remains a major global health issue, with 263 million cases and 597,000 deaths in 2023, primarily affecting young children and pregnant women. This review evaluates awareness, acceptance, hesitancy, and willingness to pay (WTP) for the RTS,S/AS01 malaria vaccine, along with the key factors influencing these outcomes.
A comprehensive literature search was conducted in Web of Science, PubMed, and Embase, covering publications up to 18 June 2024. Observational studies assessing awareness, acceptance, hesitancy, and WTP for the malaria vaccine in endemic regions were included. Two independent reviewers screened the studies. Data extraction was performed using Nested Knowledge software and analyzed with R v.4.4. Pooled prevalences were estimated using random-effects models, and heterogeneity was assessed with the I² statistic.
Eighteen studies with 21,975 participants provided insights into malaria vaccine dynamics: 32% awareness (95% CI, 18%-50%), 83% acceptance (95% CI, 75%-89%), 14% hesitancy (95% CI, 7%-26%), and 58% WTP (95% CI, 34%-79%). Key determinants of acceptance included age, where younger adults (18-24 years) showed lower acceptance (OR = 0.64, 95% CI, 0.35-0.93). Employment, particularly farmers, had higher acceptance rates (OR = 3.20, 95% CI, 1.00-7.40). Lower socioeconomic status and larger family sizes were associated with decreased acceptance (OR = 0.18, 95% CI, 0.02-0.38).
This review revealed an 83% acceptance rate for the malaria vaccine, with variability in awareness (32%), hesitancy (14%), and willingness to pay (58%). Age, employment, and socioeconomic status were significant determinants of acceptance. However, due to potential publication bias and high heterogeneity, these findings should be cautiously interpreted. The results highlight the necessity for targeted interventions to enhance vaccine acceptance. Further research is required to elucidate factors that influence vaccine acceptance.
疟疾是一种由疟原虫寄生虫引起的危及生命的疾病，通过受感染的雌性按蚊叮咬传播。它仍然是一个主要的全球健康问题，2023年有2.63亿例病例和59.7万人死亡，主要影响幼儿和孕妇。本综述评估了对RTS,S/AS01疟疾疫苗的知晓度、接受度、犹豫度和支付意愿（WTP），以及影响这些结果的关键因素。
在科学网、PubMed和Embase中进行了全面的文献检索，涵盖截至2024年6月18日的出版物。纳入了评估流行地区疟疾疫苗知晓度、接受度、犹豫度和WTP的观察性研究。两名独立的评审员筛选了这些研究。使用Nested Knowledge软件进行数据提取，并使用R v.4.4进行分析。使用随机效应模型估计合并患病率，并使用I²统计量评估异质性。
18项研究共21975名参与者提供了有关疟疾疫苗动态的见解：知晓度为32%（95%CI，18%-50%），接受度为83%（95%CI，75%-89%），犹豫度为14%（95%CI，7%-26%），支付意愿为58%（95%CI，34%-79%）。接受度的关键决定因素包括年龄，其中年轻成年人（18-24岁）的接受度较低（OR = 0.64，95%CI，0.35-0.93）。就业情况，特别是农民，接受率较高（OR = 3.20，95%CI，1.00-7.40）。社会经济地位较低和家庭规模较大与接受度降低有关（OR = 0.18，95%CI，0.02-0.38）。
本综述显示疟疾疫苗的接受率为83%，在知晓度（32%）、犹豫度（14%）和支付意愿（58%）方面存在差异。年龄、就业和社会经济地位是接受度的重要决定因素。然而，由于潜在的发表偏倚和高度异质性，这些发现应谨慎解释。结果强调了有针对性干预措施以提高疫苗接受度的必要性。需要进一步研究以阐明影响疫苗接受度的因素。
