Sorodoc Y, Danielescu G, Burducea O, Cajal N, Niclescu-Duvăz I, Baracu I
Virologie. 1977 Jan-Mar;28(1):55-61.
The nitroso-urea derivative IOB-252 was administrered in monkey kidney cell cultures in a concentration of 40 mug/ml 24 hours before inoculation of vaccinia virus and maintained afterwards in a concentration of 25 mug/ml. The drug inhibited vaccinia virus multiplication, hemagglutinin synthesis and late cytopathic effect, but did not prevent early cytopathic lesions. IOB-252 inhibited the synthesis of interferon initiated by a viral inductor and blocked the antiviral effect of an exogeneous interferon. The mechanism of action of the drug is discussed.
在接种痘苗病毒前24小时，以40微克/毫升的浓度将亚硝基脲衍生物IOB - 252施用于猴肾细胞培养物中，之后维持在25微克/毫升的浓度。该药物抑制痘苗病毒增殖、血凝素合成和晚期细胞病变效应，但不能预防早期细胞病变损伤。IOB - 252抑制由病毒诱导剂引发的干扰素合成，并阻断外源性干扰素的抗病毒作用。文中讨论了该药物的作用机制。
