Yu Sohyeon, Lee Minhyeok, Seo Dongseong, Kim Hyungjun, Park Chan-Su, Sung Daekyung
Center for Bio-Healthcare Materials, Bio-Convergence Materials R&D Division, Korea Institute of Ceramic Engineering and Technology, Cheongju, 28160, Republic of Korea; Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, 03722, Republic of Korea.
Department of Pharmaceutics, College of Pharmacy, Chungbuk National University, 1 Chungdae-ro, Seowon-gu, Cheongju, 28644, Republic of Korea.
Redox Biol. 2025 Jul;84:103659. doi: 10.1016/j.redox.2025.103659. Epub 2025 May 9.
Ascorbyl tetraisopalmitate (AT), a vitamin C derivative, exhibits better stability and transdermal absorption than vitamin C and shows potential for skin whitening and wound healing. However, their low water solubility and specific storage requirements limit their application. To overcome these limitations, in this study, we aimed to develop AT-loaded ferrocene polymer nanoparticles (AT@FNPs) using biocompatible amphiphilic polymers. The nanoprecipitated nanoparticles exhibited enhanced AT stability, loading efficiency, and controlled release in reactive oxygen species (ROS)-rich wound environments. Moreover, the ROS ROS-trigger of AT@FNPs facilitated targeted drug release and ROS scavenging, thereby enhancing the antioxidant activity. The release of AT from the AT@FNPs in wounds promoted cell proliferation and accelerated wound closure in a mouse model. Overall, our findings highlight the potential of the developed ROS-triggered AT@FNPs as smart drug delivery systems for wound healing and skin treatment.
四异棕榈酸抗坏血酸酯（AT）是一种维生素C衍生物，与维生素C相比，具有更好的稳定性和透皮吸收性，并且具有皮肤美白和伤口愈合的潜力。然而，它们的低水溶性和特定的储存要求限制了它们的应用。为了克服这些限制，在本研究中，我们旨在使用生物相容性两亲聚合物开发负载AT的二茂铁聚合物纳米颗粒（AT@FNPs）。纳米沉淀的纳米颗粒在富含活性氧（ROS）的伤口环境中表现出增强的AT稳定性、负载效率和控释性能。此外，AT@FNPs的ROS触发促进了靶向药物释放和ROS清除，从而增强了抗氧化活性。AT从AT@FNPs在伤口中的释放促进了细胞增殖，并加速了小鼠模型中的伤口闭合。总体而言，我们的研究结果突出了所开发的ROS触发的AT@FNPs作为用于伤口愈合和皮肤治疗的智能药物递送系统的潜力。
