Miettinen M, Höckerstedt K, Reitamo J, Tötterman S
Am J Clin Pathol. 1985 Sep;84(3):265-72. doi: 10.1093/ajcp/84.3.265.
Twenty-three cases of intramuscular myxoma were analyzed clinically and histologically. The mean age of the patients was 54 years, and two-thirds were women. Clinical follow-up of 2 to 17 years' duration revealed no recurrences or metastases. Intramuscular myxoma thus appears to be a completely benign tumor. One patient simultaneously had a myxoma in the muscle of the thigh and a lesion of fibrous dysplasia in the femur. In addition, 14 of 16 patients studied with x-ray had a significantly higher incidence of minor abnormalities in bones as compared with the normal population. The myxomas were characterized histologically by sparse cellularity, abundant intercellular material digestible with hyaluronidase, and lack of mitotic figures. At the ultrastructural level, the tumor cells showed characteristics of fibroblasts and myofibroblasts. Immunohistochemical analysis of intermediate filament proteins revealed vimentin- but no desmin-positivity in the tumor cells, and endothelial cell markers as well as S-100 protein were absent. This is compatible with fibroblastic-myofibroblastic nature of the myxoma cells.
对23例肌内黏液瘤进行了临床和组织学分析。患者的平均年龄为54岁，三分之二为女性。长达2至17年的临床随访显示无复发或转移。因此，肌内黏液瘤似乎是一种完全良性的肿瘤。1例患者同时在大腿肌肉中有黏液瘤，在股骨中有纤维发育不良病变。此外，与正常人群相比，16例接受X线检查的患者中有14例骨骼轻度异常的发生率明显更高。黏液瘤在组织学上的特征为细胞稀少、有可被透明质酸酶消化的丰富细胞间质且无有丝分裂象。在超微结构水平上，肿瘤细胞表现出成纤维细胞和成肌纤维细胞的特征。中间丝蛋白的免疫组织化学分析显示肿瘤细胞中波形蛋白阳性而结蛋白阴性，且不存在内皮细胞标志物和S-100蛋白。这与黏液瘤细胞的成纤维细胞-成肌纤维细胞性质相符。
