Keith T A, Cousar J B, Glick A D, Vogler L B, Collins R D
Am J Clin Pathol. 1985 Sep;84(3):283-90. doi: 10.1093/ajcp/84.3.283.
Although follicular centers are the sites of production of plasma cell precursors, plasmacytic differentiation in follicular center cell (FCC) lymphomas is rarely seen, presumably because of a "block" in differentiation of the large noncleaved FCC. The authors reviewed a large number of these cases to determine the frequency of plasmacytic differentiation in FCC lymphomas. In one hundred ninety-eight, consecutive FCC lymphomas with a follicular pattern from a two-year period, 17 (9%) cases were found in which there were large numbers of plasma cells. Immunoperoxidase studies of paraffin-embedded sections (PIP) for cytoplasmic immunoglobulin showed polytypic marking in ten of these and a monotypic plasma cell population in seven. In this latter group, isotypically identical marking of the plasma cell and FCC populations could be demonstrated in three cases with immunoperoxidase (where the FCCs showed cytoplasmic marking) and in one case (of one tested) with surface typing studies. In addition, three patients had serum paraproteins identical to the plasma cell cytoplasmic immunoglobulins. These findings indicate that a small minority of FCC lymphomas contain sufficient plasma cells to be a diagnostic problem, and that in some of these cases, plasma cells are a differentiated component of the FCC lymphomas.
尽管滤泡中心是浆细胞前体的产生部位，但在滤泡中心细胞（FCC）淋巴瘤中很少见到浆细胞分化，推测这是由于大的无裂FCC分化存在“阻滞”。作者回顾了大量此类病例，以确定FCC淋巴瘤中浆细胞分化的频率。在两年期间连续收集的198例具有滤泡模式的FCC淋巴瘤中，发现17例（9%）有大量浆细胞。对石蜡包埋切片（PIP）进行的免疫过氧化物酶研究检测细胞质免疫球蛋白，其中10例显示多型性标记，7例显示单型浆细胞群体。在后一组中，通过免疫过氧化物酶检测（FCC显示细胞质标记）在3例中可证明浆细胞和FCC群体的同型相同标记，在1例（检测的1例）通过表面分型研究也可证明。此外，3例患者的血清副蛋白与浆细胞细胞质免疫球蛋白相同。这些发现表明，一小部分FCC淋巴瘤含有足够的浆细胞，构成诊断难题，并且在其中一些病例中，浆细胞是FCC淋巴瘤的分化成分。
