Matsumoto Kotaro, Doi Shinpei, Adachi Takako, Watanabe Ayako, Katsukura Nobuhiro, Tsujikawa Takayuki, Aso Tatsuya, Takahashi Mikiko, Kikuchi Kentaro
Department of Gastroenterology, Teikyo University Mizonokuchi Hospital, Kawasaki, Japan.
Department of Clinical Pathology, Teikyo University Mizonokuchi Hospital, Kawasaki, Japan.
BMC Gastroenterol. 2025 May 14;25(1):370. doi: 10.1186/s12876-025-03961-5.
The practice of endoscopic ultrasound-guided liver biopsy (EUS-LB) is becoming more common due to its proven safety and effectiveness. For accurate diagnosis, it is vital to secure ample tissue specimens. However, gauging the volume of tissue specimens accurately poses a challenge with existing methods. Additionally, determining the most suitable fine-needle biopsy (FNB) needle requires further study. Our aim was to contrast the tissue surface areas obtained using Franseen and Fork-tip needles and to identify factors affecting tissue volume.
This retrospective study analyzed liver tissue samples collected through EUS-LB using 19-gauge Franseen and Fork-tip needles from patients suffering from diffuse liver diseases, conducted in our hospital from April 2019 to April 2022. We primarily focused on measuring hepatic tissue surface area and portal tract count, alongside examining patient-related factors that could influence tissue surface area.
The study involved 20 cases for each type of needle. The comparison revealed no significant disparities in the total liver tissue surface area (22.0 mm vs. 22.6 mm, P = 0.45) or in the portal tract counts (30 vs. 20, P = 0.16). No adverse incidents were noted in either group. Both univariate and multivariate analyses highlighted that fibrosis and metabolic dysfunction associated steatotic liver disease (MASLD) presence were significant determinants of the total hepatic tissue area (P = 0.04, P < 0.05; and P = 0.02, P = 0.03, respectively).
The capabilities of both needles in acquiring liver tissue were comparably effective. The volume of tissue was affected by the severity of fibrosis and the occurrence of MASLD.
由于已证实的安全性和有效性，内镜超声引导下肝活检（EUS-LB）的应用越来越普遍。为了准确诊断，获取足够的组织标本至关重要。然而，用现有方法准确测量组织标本的体积是一项挑战。此外，确定最合适的细针穿刺活检（FNB）针需要进一步研究。我们的目的是对比使用 Franseen 针和叉尖针获得的组织表面积，并确定影响组织体积的因素。
这项回顾性研究分析了 2019 年 4 月至 2022 年 4 月在我院对患有弥漫性肝病的患者使用 19 号 Franseen 针和叉尖针通过 EUS-LB 采集的肝组织样本。我们主要专注于测量肝组织表面积和门静脉分支数量，同时检查可能影响组织表面积的患者相关因素。
每种针型各纳入 20 例病例。比较显示，肝组织总面积（22.0 平方毫米对 22.6 平方毫米，P = 0.45）或门静脉分支数量（30 对 20，P = 0.16）均无显著差异。两组均未观察到不良事件。单因素和多因素分析均表明，纤维化和代谢功能障碍相关脂肪性肝病（MASLD）的存在是肝组织总面积的重要决定因素（分别为 P = 0.04，P < 0.05；以及 P = 0.02，P = 0.03）。
两种针获取肝组织的能力相当有效。组织体积受纤维化严重程度和 MASLD 发生情况的影响。
