Indigenous peoples in eastern North America domesticated a diverse group of annual crops. Several of these crops fell out of cultivation around the time of European colonization, and their domesticated forms are known only from the archaeological record. These crops have previously been characterized as , but in the context of a renaissance in Indigenous agriculture in this region, they are perhaps better understood as : this ancient agricultural system and its myriad ecosystem interactions could be reawakened. I briefly review the history of research on native eastern North American crops, and then synthesize recent research in terms of three themes: new models of domestication based on ecological, experimental and archaeological studies; new insights into the evolution of ancient agrobiodiversity; and an increasingly expansive understanding of the domesticated landscapes of ancient eastern North America. I conclude by suggesting some priorities for future research, and considering this sleeping agricultural system as a source of alternative crops and methods for the North American midcontinent in an era of rapid climate change.This article is part of the theme issue 'Unravelling domestication: multi-disciplinary perspectives on human and non-human relationships in the past, present and future'.