Cohen E J, Buchanan H W, Laughrea P A, Adams C P, Galentine P G, Visvesvara G S, Folberg R, Arentsen J J, Laibson P R
Am J Ophthalmol. 1985 Sep 15;100(3):389-95. doi: 10.1016/0002-9394(85)90499-4.
Diagnosis and management of Acanthamoeba chronic ulcerative keratitis is difficult. Two cases of Acanthamoeba keratitis at Wills Eye Hospital were diagnosed within several months of each other during 1983. Corneal transplantation was necessary for diagnosis and therapy in these cases. Another two cases were diagnosed when histopathologic specimens from penetrating keratoplasties done between 1974 and 1983 were reviewed retrospectively. There has been no evidence of recurrent disease in any of our cases during follow-up periods averaging two years (range, 12 to 40 months). The diagnosis of Acanthamoeba keratitis must be considered in cases of chronic progressive corneal ulceration unresponsive to medical therapy.
棘阿米巴慢性溃疡性角膜炎的诊断和治疗颇具难度。1983年，威尔斯眼科医院在几个月内相继诊断出两例棘阿米巴角膜炎。在这些病例中，角膜移植对于诊断和治疗均很必要。另外两例是在对1974年至1983年间进行的穿透性角膜移植术的组织病理学标本进行回顾性研究时确诊的。在平均为期两年（范围为12至40个月）的随访期内，我们的任何病例均未出现疾病复发的迹象。对于药物治疗无反应的慢性进行性角膜溃疡病例，必须考虑棘阿米巴角膜炎的诊断。
