单次口服给药后纳多洛尔在房水中的渗透情况。
Penetration of nadolol into aqueous humour after a single oral dose.
作者信息
Tiong T H, Hung S O, Perelman M S
机构信息
Warrington District Hospital.
出版信息
Br J Clin Pharmacol. 1988 Jul;26(1):92-5. doi: 10.1111/j.1365-2125.1988.tb03369.x.
Abstract
Nadolol 20 mg was administered orally as a single-blind, single dose to nine patients about to undergo cataract extraction. Intraocular pressures fell by a mean of 24% 3 h after administration. During the operation, aqueous humour and serum samples were taken for measurement of nadolol concentrations. Aqueous nadolol concentrations ranged from 3.8 to 13.4 ng ml-1, and correlated with the serum drug concentrations (r = 0.84). The fall in intraocular pressure did not correlate with either the aqueous humour or plasma concentrations of nadolol.
摘要
对9名即将接受白内障摘除术的患者进行单盲单剂量口服20毫克纳多洛尔治疗。给药后3小时眼压平均下降24%。手术期间，采集房水和血清样本以测量纳多洛尔浓度。房水中纳多洛尔浓度范围为3.8至13.4纳克/毫升，并与血清药物浓度相关（r = 0.84）。眼压下降与房水或血浆中纳多洛尔浓度均无相关性。
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