Gao Yuan, Wang Bo, Wang Shuai, Jiang Yanyan, Wang Dalong, Lin Quan, Liu Ke, Zhang Shuai, Cheng Ying, Xu Jimei
Department of Anesthesiology, Jingzhou Hospital Affiliated to Yangtze University, No. 4, Renmin Road, Jingzhou District, Jingzhou 434020, Hubei Province, China.
Department of Anesthesiology, PLA 63600 Hospital, Base 10, Jinta County, Jiuquan 735000, Gansu Province, China.
Toxicol Res (Camb). 2025 May 13;14(3):tfaf068. doi: 10.1093/toxres/tfaf068. eCollection 2025 Jun.
The perioperative respiratory adverse events (PRAE) are ineluctable during pediatric anesthesia. Accurate assessment of preoperative anesthesia is significant to reduce surgical risks in general anesthesia. This study focused on the expression level and predictive performance of lncRNA MALAT1 in PRAE for general anesthesia children. 236 medical records from children patients were included and they were divided into the No-PRAE group ( = 129) and the PRAE group ( = 107). Blood samples obtained before general anesthesia were used to evaluate the relative levels of MALAT1 by qRT-PCR. The multivariate logistic regression analysis was carried out to identify underlying risk factors. The receiver operator characteristic (ROC) curve was plotted to estimate the diagnostic performance of MALAT1 in the occurrence of PRAE. The serum MALAT1 in the PRAE group was identified to be higher than that in the No-PRAE group. The regression analysis indicated that patients with preoperative airway disease (OR: 2.813; 95%CI: 1.327-5.961) or longer anesthesia duration (OR: 2.131; 95%CI: 1.111-4.088) or higher levels of MALAT1 (OR: 13.019; 95%CI: 6.769-25.039) faced a higher risk of PRAE. The area under the ROC curve was 0.885 while the sensitivity and specificity were 79.44% and 82.17%, respectively, identifying the referrible value of MALAT1 as a risk factor for predicting PRAE in general anesthesia children. In conclusion, the increased MALAT1 was a potential indicator of predicting PRAE in general anesthesia children.
围手术期呼吸不良事件（PRAE）在小儿麻醉期间难以避免。准确评估术前麻醉对降低全身麻醉的手术风险具有重要意义。本研究聚焦于lncRNA MALAT1在全身麻醉儿童PRAE中的表达水平及预测性能。纳入236例儿童患者的病历资料，并将其分为无PRAE组（n = 129）和PRAE组（n = 107）。采集全身麻醉前的血样，采用qRT-PCR评估MALAT1的相对水平。进行多因素逻辑回归分析以确定潜在危险因素。绘制受试者工作特征（ROC）曲线以评估MALAT1在PRAE发生中的诊断性能。结果显示，PRAE组血清MALAT1高于无PRAE组。回归分析表明，术前患有气道疾病（OR：2.813；95%CI：1.327 - 5.961）、麻醉持续时间较长（OR：2.131；95%CI：1.111 - 4.088）或MALAT1水平较高（OR：13.019；95%CI：6.769 - 25.039）的患者发生PRAE的风险更高。ROC曲线下面积为0.885，敏感性和特异性分别为79.44%和82.17%，表明MALAT1作为预测全身麻醉儿童PRAE风险因素具有参考价值。总之，MALAT1升高是预测全身麻醉儿童PRAE的潜在指标。
