Xia Ping, Shi Xiaolong, Yang Yunling, Zhang Yanru, Hu Xuyang, Lin Rong, Weng Xiaoying, Shen Fenfang, Chen Xiaobao, Lin Liang
Medical Centre of Maternity and Child Health, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.
Department of Urology, Fujian Medical University Union Hospital, Fuzhou, China.
Front Nutr. 2025 Apr 30;12:1439134. doi: 10.3389/fnut.2025.1439134. eCollection 2025.
Magnesium regulates vascular smooth muscle contraction, with implications for cardiovascular diseases. However, the population-level relevance of magnesium homeostasis to urinary incontinence (UI) subtypes and associated mortality remains unexamined.
The National Health and Nutrition Examination Survey (NHANES) were utilized to investigate the association between magnesium depletion score (MDS) and urinary incontinence (UI) from 2005 to 2018. Weighted multivariate regression analyses and multivariate Cox regression analyses were used to analysis. Additionally, subgroup analyses and multiple imputations (MI) were carried out as sensitivity analyses to ensure the strength and reliability of the findings.
A total of 16,197 individuals were included in the study, with 6,881 of them experiencing urinary incontinence (UI). Among those with UI, 767 cases of all-cause mortality were documented. The prevalence rates were 42.83% for stress urinary incontinence (SUI), 27.85% for urgency urinary incontinence (UUI), and 16.82% for mixed urinary incontinence (MUI). Results from weighted logistic regression analysis demonstrated a positive relationship between MDS and SUI (OR 1.09, 95% CI: 1.01-1.17), UUI (OR 1.14, 95% CI: 1.06-1.22), and MUI (OR 1.22, 95% CI: 1.11-1.35). Additionally, higher MDS values were associated with increased severity of urinary incontinence. These findings were further supported by various sensitivity analyses. Furthermore, survey-weighted Cox proportional hazards regression indicated a positive association between MDS and all-cause mortality regardless of (OR 1.27, 95% CI: 1.13-1.41), suggesting that higher MDS independently predicts worse prognosis.
MDS is an important risk factor for the prevalence and mortality rates of UI. Monitoring magnesium status may inform UI prevention strategies. Interpretation should consider limitations including observational design and lack of serum magnesium levels.
镁可调节血管平滑肌收缩，与心血管疾病相关。然而，镁稳态在人群水平上与尿失禁（UI）亚型及相关死亡率之间的相关性尚未得到研究。
利用美国国家健康与营养检查调查（NHANES）来研究2005年至2018年期间镁缺乏评分（MDS）与尿失禁（UI）之间的关联。采用加权多变量回归分析和多变量Cox回归分析进行分析。此外，进行亚组分析和多重填补（MI）作为敏感性分析，以确保研究结果的强度和可靠性。
该研究共纳入16197名个体，其中6881人患有尿失禁（UI）。在患有UI的人群中，记录了767例全因死亡病例。压力性尿失禁（SUI）的患病率为42.83%，急迫性尿失禁（UUI）为27.85%，混合性尿失禁（MUI）为16.82%。加权逻辑回归分析结果显示，MDS与SUI（比值比1.09，95%置信区间：1.01 - 1.17）、UUI（比值比1.14，95%置信区间：1.06 - 1.22）和MUI（比值比1.22，95%置信区间：1.11 - 1.35）之间呈正相关。此外，较高的MDS值与尿失禁严重程度增加相关。各种敏感性分析进一步支持了这些发现。此外，调查加权Cox比例风险回归表明，MDS与全因死亡率之间存在正相关（比值比1.27，95%置信区间：1.13 - 1.41），这表明较高的MDS独立预测预后较差。
MDS是UI患病率和死亡率的重要危险因素。监测镁状态可能为UI预防策略提供参考。解释时应考虑包括观察性设计和缺乏血清镁水平等局限性。
