Yu Jintao, Liang Yi, Thompson Simon, Cull Grant, Wang Lin
Discoveries in Sight Research Laboratories, Devers Eye Institute, Legacy Research Institute Portland, Oregon ; School of Computer and Information Engineering, Harbin University of Commerce Harbin, China.
Discoveries in Sight Research Laboratories, Devers Eye Institute, Legacy Research Institute Portland, Oregon.
Int J Physiol Pathophysiol Pharmacol. 2014 Mar 13;6(1):13-22. eCollection 2014.
The aim of the study was to establish a parametric transfer function to describe the relationship between ocular perfusion pressure (OPP) and blood flow (BF) in the optic nerve head (ONH). A third-order parametric theoretical model was proposed to describe the ONH OPP-BF relationship within the lower OPP range of the autoregulation curve (< 80 mmHg) based on experimentally induced BF response to a rapid intraocular pressure (IOP) increase in 6 rhesus monkeys. The theoretical and actual data fitted well and suggest that this parametric third-order transfer function can effectively describe both the linear and nonlinear feature in dynamic and static autoregulation in the ONH within the OPP range studied. It shows that the BF autoregulation fully functions when the OPP was > 40 mmHg and becomes incomplete when the OPP was < 40 mmHg. This model may be used to help investigating the features of autoregulation in the ONH under different experimental conditions.
本研究的目的是建立一个参数传递函数，以描述视神经乳头（ONH）的眼灌注压（OPP）与血流（BF）之间的关系。基于对6只恒河猴快速眼压（IOP）升高的实验诱导BF反应，提出了一个三阶参数理论模型，以描述自动调节曲线较低OPP范围（<80 mmHg）内的ONH OPP-BF关系。理论数据与实际数据拟合良好，表明该参数三阶传递函数可以有效描述所研究OPP范围内ONH动态和静态自动调节中的线性和非线性特征。结果表明，当OPP>40 mmHg时，BF自动调节功能完全发挥作用，而当OPP<40 mmHg时，BF自动调节功能不完全。该模型可用于帮助研究不同实验条件下ONH自动调节的特征。
