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病例报告:表现为多发性干酪样心包肿块的肺外结核

Case Report: Extrapulmonary tuberculosis presenting as multiple caseous pericardial masses.

作者信息

Wang Juan, Zhang Run, Li Zhengliang, Fang Hui, Zhang Wenzhong

机构信息

Department of Cardiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

出版信息

Front Cardiovasc Med. 2025 Apr 30;12:1529400. doi: 10.3389/fcvm.2025.1529400. eCollection 2025.

DOI:10.3389/fcvm.2025.1529400
PMID:40371065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12076156/
Abstract

The diagnosis of tuberculous pericarditis presenting as a hemorrhagic pericardial effusion is not difficult to make, but the presence of multiple pericardial masses in tuberculous pericarditis is uncommon. The article reports a 55-year-old Asian woman with a 10-day history of fever, chest tightness and shortness of breath. Laboratory investigations revealed an elevated C-reactive protein and erythrocyte sedimentation rate, and echocardiography showed a small amount of pericardial effusion associated with multiple pericardial caseous masses (up to approximately 2.4 cm × 6.9 cm) without pericardial constriction. Ten ml of bloody pericardial effusion was punctured and sent for pathology without malignant cells, and malignant mesothelioma was excluded in combination with PET-CT results. The diagnosis of extrapulmonary tuberculosis was finally confirmed by a positive Mantoux test and positive tuberculosis immunoreactivity, and the patient is now receiving standardized anti-tuberculosis treatment in a specialist hospital. Nowadays, the diagnosis of tuberculous pericarditis is not difficult, but the symptoms of a concomitant giant mass are rare, and its nature and treatment options (including drugs or surgery) are worth exploring.

摘要

以出血性心包积液为表现的结核性心包炎诊断并不困难,但结核性心包炎中出现多个心包肿块的情况并不常见。本文报道了一名55岁的亚洲女性,有10天的发热、胸闷和气短病史。实验室检查显示C反应蛋白和红细胞沉降率升高,超声心动图显示少量心包积液,伴有多个心包干酪样肿块(最大约2.4 cm×6.9 cm),无心包缩窄。抽取10毫升血性心包积液送检病理,未见恶性细胞,结合PET-CT结果排除恶性间皮瘤。最终通过结核菌素试验阳性和结核免疫反应阳性确诊为肺外结核,患者现正在专科医院接受标准化抗结核治疗。如今,结核性心包炎的诊断并不困难,但伴有巨大肿块的症状罕见,其性质及治疗方案(包括药物或手术)值得探讨。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2172/12076156/f6e53fceefb8/fcvm-12-1529400-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2172/12076156/f6e53fceefb8/fcvm-12-1529400-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2172/12076156/f6e53fceefb8/fcvm-12-1529400-g001.jpg

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Orbital tuberculosis presenting as vision loss and headache: early management is paramount.以视力丧失和头痛为表现的眼眶结核:早期治疗至关重要。
J Ophthalmic Inflamm Infect. 2024 Oct 14;14(1):51. doi: 10.1186/s12348-024-00425-x.
2
Primary Tuberculous Pyomyositis of the Left Forearm Muscles.左前臂肌肉原发性结核性脓性肌炎
Infect Dis Clin Microbiol. 2024 Sep 26;6(3):248-251. doi: 10.36519/idcm.2024.360. eCollection 2024 Sep.
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Tuberculous Pericardial Effusion With Pleural Effusion in an Indian Female: A Rare Case.一名印度女性患结核性心包积液伴胸腔积液:罕见病例
Cureus. 2024 May 2;16(5):e59546. doi: 10.7759/cureus.59546. eCollection 2024 May.
4
Extrapulmonary tuberculosis presenting as hemorrhagic pleuro-pericardial effusions with pericardial mass.表现为出血性胸膜心包积液伴心包肿块的肺外结核
Clin Case Rep. 2024 Mar 31;12(4):e8619. doi: 10.1002/ccr3.8619. eCollection 2024 Apr.
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GeneXpert MTB/RIF Ultra vs Unstimulated Interferon γ (IRISA-TB) for the Diagnosis of Tuberculous Pericarditis in a Tuberculosis-Endemic Setting.在结核病流行地区,GeneXpert MTB/RIF Ultra与未刺激的干扰素γ(IRISA-TB)用于诊断结核性心包炎的比较
Open Forum Infect Dis. 2024 Mar 20;11(3):ofae021. doi: 10.1093/ofid/ofae021. eCollection 2024 Mar.
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Pancreatic tuberculosis mimicking as pancreatic malignancy: Surgeon's dilemma.酷似胰腺恶性肿瘤的胰腺结核:外科医生的困境
Indian J Pathol Microbiol. 2023 Jul-Sep;66(3):614-617. doi: 10.4103/ijpm.ijpm_874_21.
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Diagnosis of tuberculous pericarditis with transgastric EUS fine-needle aspiration (with video).经胃超声内镜细针穿刺诊断结核性心包炎(附视频)
Gastrointest Endosc. 2024 Jan;99(1):118-119. doi: 10.1016/j.gie.2023.07.007. Epub 2023 Jul 7.
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