Morissette Florence, Coulombe Jérome
Dermatology Division, Department of Medicine, CHUM, University of Montreal, QC, Canada.
Dermatology Division, Department of Pediatrics, CHU Sainte-Justine, Montreal, QC, Canada.
SAGE Open Med Case Rep. 2025 May 13;13:2050313X251341558. doi: 10.1177/2050313X251341558. eCollection 2025.
Actinic prurigo is a rare photodermatosis, usually occurring during childhood. Pruritic papulonodules on sun-exposed areas are frequently associated with cheilitis and conjunctivitis. The most widely accepted pathophysiology to date is a type IV hypersensitivity reaction triggered by ultraviolet radiation. This case report describes a 12-year-old boy suffering from refractory actinic prurigo, who was successfully treated with the janus kinase inhibitor upadacitinib.
光化性痒疹是一种罕见的光皮肤病，通常发生于儿童期。暴露于阳光下的部位出现瘙痒性丘疹结节常伴有唇炎和结膜炎。迄今为止最被广泛接受的病理生理学是由紫外线辐射引发的IV型超敏反应。本病例报告描述了一名患有难治性光化性痒疹的12岁男孩，他用JAK激酶抑制剂乌帕替尼成功治愈。
