Hojyo-Tomoka T, Granados J, Vargas-Alarcón G, Yamamoto-Furusho J K, Vega-Memije E, Cortés-Franco R, Flores O, Teixeira F, Domínguez-Soto L
Department of Dermatology, Hospital General Dr. Manuel Gea González, Tlalpan D.F., Mexico.
J Am Acad Dermatol. 1997 Jun;36(6 Pt 1):935-7. doi: 10.1016/s0190-9622(97)80276-9.
Actinic prurigo (AP) is triggered by sun exposure. Its prevalence in Mexicans seems to be particularly high, which suggests a genetic susceptibility.
Our purpose was to determine the role of major histocompatibility complex (MHC) genes in the genetic susceptibility to AP.
Fifty-six Mexican Mestizo patients with AP underwent serologic typing for HLA class I and class II antigens. Class II MHC genes were also studied by DNA analysis. Findings in patients were compared with 100 ethnically matched healthy controls.
We found that 92.8% of patients with AP were HLA-DR4 positive (corrected p = 0.002; odds ratio [OR] = 10.1). The class I antigens HLA-A28 and HLA-B39 (B16) were also significantly increased (p < or = 0.000001, OR = 20.9 and p = 0.0001, OR = 6.7, respectively) compared with normal controls. Allele-specific oligonucleotide DR4 subtyping showed that 80.7% of HLA-DR4+ patients with AP were also positive for the DRB1*0407 allele.
These results confirm the role of HLA-DR4 (DRB1*0407) in the genetic susceptibility to AP and raise the possibility of a role for class I MHC antigens HLA-A28 and B16 in Mexican patients.
光化性痒疹（AP）由阳光照射引发。其在墨西哥人中的患病率似乎特别高，这表明存在遗传易感性。
我们的目的是确定主要组织相容性复合体（MHC）基因在AP遗传易感性中的作用。
56例患有AP的墨西哥梅斯蒂索患者接受了HLA I类和II类抗原的血清学分型。还通过DNA分析研究了II类MHC基因。将患者的结果与100名种族匹配的健康对照进行比较。
我们发现92.8%的AP患者HLA-DR4呈阳性（校正p = 0.002；优势比[OR] = 10.1）。与正常对照相比，I类抗原HLA-A28和HLA-B39（B16）也显著增加（分别为p≤0.000001，OR = 20.9和p = 0.0001，OR = 6.7）。等位基因特异性寡核苷酸DR4亚型分析显示，80.7%的AP HLA-DR4+患者DRB1*0407等位基因也呈阳性。
这些结果证实了HLA-DR4（DRB1*0407）在AP遗传易感性中的作用，并增加了I类MHC抗原HLA-A28和B16在墨西哥患者中起作用的可能性。
