Aunan-Diop Jan Saip, Friismose Ancuta Ioana, Halle Bo, Pedersen Christian Bonde, Mussmann Bo, Hojo Emi, Yin Ziying, Nortvig Mathias Just, Lagerstrand Kerstin, Poulsen Frantz Rom
Department of Neurosurgery, Odense University Hospital, Odense, Denmark.
Department of Clinical Research, University of Southern Denmark, BRIDGE (Brain Research Inter Disciplinary Guided Excellence), University of Southern Denmark, Odense, Denmark.
J Magn Reson Imaging. 2025 May 15. doi: 10.1002/jmri.29825.
Magnetic resonance elastography (MRE) quantifies tissue viscoelasticity, offering insights into intracranial meningiomas. MRE-derived parameters, including the storage modulus (G') and the magnitude of the complex modulus (|G*|), may aid neurosurgical planning, but their repeatability remains unexplored in brain tumors.
PURPOSE/HYPOTHESIS: To evaluate the repeatability of G' and |G*| in meningiomas, the influence of tumor volume and spatial location on variability, and ranking stability across paired elastograms.
Prospective.
POPULATION/SUBJECTS: Seventeen paired MRE scans from 16 patients with meningiomas (mean age 64 ± 12 years, 10 females) scheduled for resection.
FIELD STRENGTH/SEQUENCE: MRE was performed on a 3 T system using a single-shot spin-echo echo-planar imaging (SE-EPI) sequence.
Tumors were segmented on contrast-enhanced T1-weighted images; distance and volume metrics were extracted. Regions of interest were applied to G' and |G*| elastograms. Repeatability was evaluated using the coefficient of variation (CV%). Ranking stability was assessed by comparing median G' or |G*| values.
The difference in CV% was assessed using the Wilcoxon signed rank test. Linear regression assessed the effect of tumor volume and distance from the external occipital protuberance (EOP) on CV%. The Wilcoxon signed-rank test evaluated ranking stability and scan-rescan CV%. Statistical significance was defined as p < 0.05.
The difference in CV% G' (14.89 ± 12.32) and CV% |G*| (13.88 ± 12.60) was not significant (p = 0.61). Tumor volume inversely correlated with CV% (G': β = -0.75 |G*|: β = -0.59). Tumor-EOP distance had no significant effect (G': p = 0.58, |G*|: p = 0.23). Rankings remained stable (G': p = 0.82, |G*|: p = 0.71).
MRE-derived parameters are repeatable in intracranial meningiomas, with G' and |G*| being equally stable. Larger tumors yielded more consistent estimates. Preserved ranking stability supports the use of MRE in preoperative planning.
Stage 2.
磁共振弹性成像（MRE）可量化组织粘弹性，为颅内脑膜瘤的研究提供了新视角。MRE得出的参数，包括储能模量（G'）和复模量幅值（|G*|），可能有助于神经外科手术规划，但它们在脑肿瘤中的可重复性仍未得到探索。
目的/假设：评估G'和|G*|在脑膜瘤中的可重复性、肿瘤体积和空间位置对变异性的影响，以及配对弹性成像图之间的排序稳定性。
前瞻性研究。
对16例计划进行切除术的脑膜瘤患者（平均年龄64±12岁，10名女性）进行了17组配对的MRE扫描。
场强/序列：在3T系统上使用单次激发自旋回波平面成像（SE-EPI）序列进行MRE检查。
在对比增强T1加权图像上对肿瘤进行分割；提取距离和体积指标。在G'和|G*|弹性成像图上设置感兴趣区域。使用变异系数（CV%）评估可重复性。通过比较G'或|G*|的中位数评估排序稳定性。
使用Wilcoxon符号秩检验评估CV%的差异。线性回归评估肿瘤体积和距枕外隆凸（EOP）的距离对CV%的影响。Wilcoxon符号秩检验评估排序稳定性和扫描-重扫CV%。统计学显著性定义为p<0.05。
G'的CV%（14.89±12.32）与|G*|的CV%（13.88±12.60）之间的差异无统计学意义（p=0.61）。肿瘤体积与CV%呈负相关（G'：β=-0.75；|G*|：β=-0.59）。肿瘤与EOP的距离无显著影响（G'：p=0.58，|G*|：p=0.23）。排序保持稳定（G'：p=0.82，|G*|：p=0.71）。
MRE得出的参数在颅内脑膜瘤中具有可重复性，G'和|G*|同样稳定。较大的肿瘤得出的估计值更一致。排序稳定性得以保留，支持在术前规划中使用MRE。
2级。
2级。
