Ishikawa K, Igarashi M
Am J Otolaryngol. 1985 Jul-Aug;6(4):290-6. doi: 10.1016/s0196-0709(85)80057-0.
The central cholinergic system's involvement in vestibular compensation has been clearly demonstrated in the infra-human primate model. In the squirrel monkey, long after unilateral labyrinthectomy, atropine injection produced significant reduction of slow-phase eye velocity of the spontaneous nystagmus. The atropine effect was also depicted through the dynamic vestibular inputs, reducing the maximum slow-phase eye velocity of damped pendular rotation nystagmus. Contrary results (increased slow-phase eye velocities) were found after carbachol injection. After atropine injection, the locomotor deviation count increased significantly, more to the nonlesion side. Carbachol injection engendered the opposite result. After bilateral labyrinthectomy, no significant effect was found from drug injection. Thus, our findings suggest that atropine's major site of action after unilateral labyrinthectomy is the vestibular nuclei on the intact side.
在非人灵长类动物模型中，中枢胆碱能系统参与前庭代偿已得到明确证实。在松鼠猴中，单侧迷路切除术后很长时间，注射阿托品会使自发性眼球震颤的慢相眼速度显著降低。阿托品的作用也通过动态前庭输入得以体现，降低了阻尼摆旋转性眼球震颤的最大慢相眼速度。注射卡巴胆碱后则发现了相反的结果（慢相眼速度增加）。注射阿托品后，运动偏差计数显著增加，更多地偏向非损伤侧。注射卡巴胆碱产生了相反的结果。双侧迷路切除术后，药物注射未发现显著效果。因此，我们的研究结果表明，单侧迷路切除术后阿托品的主要作用部位是完整侧的前庭核。
