Henley C, Igarashi M
Department of Otorhinolaryngology & Communicative Sciences, Baylor College of Medicine, Houston, Texas.
Acta Otolaryngol. 1993 May;113(3):235-8. doi: 10.3109/00016489309135799.
Polyamine synthesis increases in response to injurious stimuli including axotomy and denervation. Reduced eye nystagmus and head-deviation have been observed in unilateral labyrinthectomized (UL) guinea pigs treated with an inhibitor of polyamine synthesis, alpha-difluoromethylornithine (DFMO). We quantified polyamines in the lateral vestibular nuclei (LVN) of control and UL squirrel monkeys during the phase of vestibular compensation (VC) and performed an experiment to determine if DFMO reduces nystagmus previously observed in the guinea pig. Polyamines were detected in the LVN of control and UL squirrel monkeys. Putrescine and spermidine increased in the ipsilateral LVN 3 days after UL with no change in the contralateral LVN. No left-right differences were noted in the 5-day post-UL monkey. DFMO reduced nystagmus in a UL squirrel monkey. These findings suggest that polyamines are important in vestibular function and may contribute to nystagmus observed in VC.
多胺合成会因包括轴突切断术和去神经支配在内的损伤性刺激而增加。在用多胺合成抑制剂α-二氟甲基鸟氨酸（DFMO）治疗的单侧迷路切除（UL）豚鼠中，观察到眼球震颤和头部偏斜减少。我们在松鼠猴前庭代偿（VC）阶段对对照和UL松鼠猴的外侧前庭核（LVN）中的多胺进行了定量，并进行了一项实验，以确定DFMO是否能减少先前在豚鼠中观察到的眼球震颤。在对照和UL松鼠猴的LVN中检测到了多胺。UL后3天，同侧LVN中的腐胺和亚精胺增加，对侧LVN无变化。在UL后5天的猴子中未发现左右差异。DFMO减少了一只UL松鼠猴的眼球震颤。这些发现表明，多胺在前庭功能中很重要，可能与VC中观察到的眼球震颤有关。
