Dufty J H, Outteridge P M
Anim Blood Groups Biochem Genet. 1985;16(2):85-92. doi: 10.1111/j.1365-2052.1985.tb01457.x.
Studies were carried out to determine the time of appearance, frequency, titre and specificity of lymphocytotoxic antibodies in the plasma of parous Hereford cattle. Cytotoxic antibody was first detected in a small proportion (3/62 = 4.8%) of primigravid cattle during the last third of pregnancy. Titres were low (neat or 1 in 2) at this time and decreased in one animal so that antibodies were not detectable in samples obtained on the day of calving or 9 days beforehand. Following parturition, the proportion of primiparous cattle producing lymphocytotoxic antibodies increased markedly and reached a maximum value (8/19 = 42.1%) during the third month post partum. Antibody levels also rose over the same period. An increase in the parity of the dam also resulted in an increase in the proportion of cattle with lymphocytotoxic plasma. These antibodies appeared earlier in pregnancy, were at a higher titre and had a wider specificity than those found in primigravida. Non-foetally stimulated antibody was detected in 4 cattle. In one plasma sample, lymphocytotoxic activity was present prior to mating, and in the 3 others it was not directed against cells from either the bull to which the dam was mated or the calf produced by the sire and dam.
开展了多项研究，以确定经产海福特牛血浆中淋巴细胞毒性抗体的出现时间、频率、滴度和特异性。在妊娠最后三分之一阶段，首次在一小部分（3/62 = 4.8%）初产牛中检测到细胞毒性抗体。此时滴度较低（原液或1:2），且其中一只动物的滴度下降，以至于在产犊当天或提前9天采集的样本中未检测到抗体。分娩后，初产牛产生淋巴细胞毒性抗体的比例显著增加，并在产后第三个月达到最大值（8/19 = 42.1%）。同期抗体水平也有所上升。母体胎次增加也导致具有淋巴细胞毒性血浆的牛的比例增加。这些抗体在妊娠早期出现，滴度更高，特异性比初产牛中发现的抗体更广。在4头牛中检测到非胎儿刺激产生的抗体。在一份血浆样本中，交配前就存在淋巴细胞毒性活性，而在其他3份样本中，其并非针对与母体交配的公牛的细胞，也不是针对该公牛与母体所生小牛的细胞。
