多机构脑转移瘤图谱为精准成像和个性化治疗的空间建模提供信息。

Multi-institutional atlas of brain metastases informs spatial modeling for precision imaging and personalized therapy.

作者信息

Barrios Jorge, Porter Evan, Capaldi Dante P I, Upadhaya Taman, Chen William C, Perks Julian R, Apte Aditya, Aristophanous Michalis, LoCastro Eve, Hsu Dylan, Stone Payton H, Villanueva-Meyer Javier E, Valdes Gilmer, Jiang Fei, Maddalena Michael, Ballangrud Ase, Prezelski Kayla, Lin Hui, Sun Jinger Y, Aldin Muhtada A K, Chau Oi Wai, Ziemer Benjamin, Seaberg Maasa, Sneed Penny K, Nakamura Jean L, Boreta Lauren C, Fogh Shannon E, Raleigh David R, Chew Jessica, Vasudevan Harish, Cha Soonmee, Hess Christopher, Fragoso Ruben, Shultz David B, Pike Luke, Hervey-Jumper Shawn L, Tsang Derek S, Theodosopoulos Philip, Cooke Daniel, Benedict Stanley H, Sheng Ke, Seuntjens Jan, Coolens Catherine, Deasy Joe, Braunstein Steve, Morin Olivier

机构信息

Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA.

Department of Radiation Oncology, University of California Davis Health, Sacramento, CA, USA.

出版信息

Nat Commun. 2025 May 15;16(1):4536. doi: 10.1038/s41467-025-59584-7.

DOI:10.1038/s41467-025-59584-7

PMID:40374598

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12081687/

Abstract

Brain metastases are a frequent and debilitating manifestation of advanced cancer. Here, we collect and analyze neuroimaging of 3,065 cancer patients with 13,067 brain metastases, representing an extensive collection for research. We find that metastases predominantly localize to high perfusion areas near the grey-white matter junction, but also identify notable differences depending on the primary cancer histology as well as brain regions which do not conform to this relationship. Lung and breast cancers, in contrast to melanoma, frequently metastasize to the cerebellum, hinting at biological pathways of spread. Additionally, the deep brain structures are relatively spared from metastasis, regardless of primary cancer type. Leveraging this data, we propose a probabilistic brain metastasis risk model to enhance the therapeutic ratio of whole-brain radiotherapy by targeting high risk areas while preserving cortical and subcortical brain regions of functional significance and low metastasis risk, potentially reducing the cognitive side effects of therapy.

摘要

脑转移是晚期癌症常见且使人衰弱的表现。在此，我们收集并分析了3065例患有13067处脑转移瘤的癌症患者的神经影像，这是一个用于研究的广泛数据集。我们发现转移瘤主要定位于灰白质交界处附近的高灌注区域，但也发现根据原发癌组织学以及不符合这种关系的脑区存在显著差异。与黑色素瘤相比，肺癌和乳腺癌经常转移至小脑，这提示了转移的生物学途径。此外，无论原发癌类型如何，深部脑结构相对较少发生转移。利用这些数据，我们提出了一种概率性脑转移风险模型，通过靶向高风险区域，同时保留具有功能意义且转移风险低的皮质和皮质下脑区，提高全脑放疗的治疗比， potentially reducing the cognitive side effects of therapy.（此处原文有拼写错误，正确的应该是“potentially reducing the cognitive side effects of therapy”，翻译为“潜在地降低治疗的认知副作用”）从而潜在地降低治疗的认知副作用。