Zhao Kun, Ma Hongfeng
Department of Otolaryngology, Tianjin Fifth Central Hospital, No. 41 Zhejiang Road, Tanggu, Binhai New District, Tianjin City 300450, China.
Department of Otolaryngology, Tianjin Fifth Central Hospital, No. 41 Zhejiang Road, Tanggu, Binhai New District, Tianjin City 300450, China.
Am J Otolaryngol. 2025 Jul-Aug;46(4):104671. doi: 10.1016/j.amjoto.2025.104671. Epub 2025 May 8.
To evaluate the prognostic value of SII and LMR in predicting hearing recovery outcomes in profound SSHL cases.
The relationships between inflammatory markers and hearing outcomes were assessed using univariate and multivariate logistic regression analyses. Receiver operating characteristic (ROC) curve analysis was performed to assess the predictive accuracy of SII and LMR for recovery outcomes.
The study revealed that SII and LMR were linked to hearing recovery in profound SSHL. Cases in the complete recovery group had significantly lower SII (806.57 ± 217.26) and higher LMR (2.14 ± 0.94) compared to those in the partial and no recovery groups (P < 0.001 for both). Multivariate logistic regression identified Tbil, SII, and LMR as independent predictors of recovery outcomes. Higher SII and lower LMR were significantly associated with poor recovery, while lower SII and higher LMR predicted better recovery. ROC curve analysis showed that SII and LMR had moderate predictive power for partial recovery (AUC: 0.668 for SII, 0.696 for LMR) and excellent predictive power for no recovery (AUC: 0.804 for SII, 0.819 for LMR). The combination of SII and LMR further enhanced predictive accuracy (AUC: 0.879 for no recovery).
SII and LMR are valuable biomarkers for predicting recovery outcomes in cases with profound SSHL. Elevated SII and reduced LMR are associated with poor recovery, while lower SII and higher LMR suggest a favorable prognosis. The combined use of these markers improves the accuracy of prognosis prediction and could guide clinical management in SSHL cases.
评估全身炎症反应指数（SII）和淋巴细胞与单核细胞比值（LMR）在预测重度突发性聋（SSHL）患者听力恢复结局中的预后价值。
采用单因素和多因素逻辑回归分析评估炎症标志物与听力结局之间的关系。进行受试者工作特征（ROC）曲线分析，以评估SII和LMR对恢复结局的预测准确性。
研究表明，SII和LMR与重度SSHL的听力恢复有关。与部分恢复组和未恢复组相比，完全恢复组的病例SII显著更低（806.57±217.26），LMR显著更高（2.14±0.94）（两者P均<0.001）。多因素逻辑回归确定总胆红素（Tbil）、SII和LMR为恢复结局的独立预测因素。SII越高、LMR越低与恢复不良显著相关，而SII越低、LMR越高则预测恢复较好。ROC曲线分析表明，SII和LMR对部分恢复具有中等预测能力（SII的AUC为0.668，LMR的AUC为0.696），对未恢复具有优异预测能力（SII的AUC为0.804，LMR的AUC为0.819）。SII和LMR联合使用进一步提高了预测准确性（未恢复的AUC为0.879）。
SII和LMR是预测重度SSHL患者恢复结局的有价值生物标志物。SII升高和LMR降低与恢复不良相关，而SII降低和LMR升高提示预后良好。联合使用这些标志物可提高预后预测的准确性，并可为SSHL病例的临床管理提供指导。
