Sholar P W, Bell W R
Ann Intern Med. 1985 Oct;103(4):539-41. doi: 10.7326/0003-4819-103-4-539.
Two patients with paroxysmal nocturnal hemoglobinuria had increasing abdominal girth and ascites. The Budd-Chiari syndrome or inferior vena cava thrombosis was shown by angiography. After thrombolytic therapy, both patients improved, and thrombolysis was shown by radiography. Neither patient had induction of hemolysis secondary to these agents. These studies suggest that both streptokinase and urokinase are safe and effective in the treatment of intra-abdominal venous thromboses associated with paroxysmal nocturnal hemoglobinuria.
两名阵发性夜间血红蛋白尿患者出现腹围增加和腹水。血管造影显示布加综合征或下腔静脉血栓形成。经溶栓治疗后，两名患者均有改善，影像学检查显示血栓溶解。两名患者均未因这些药物诱发溶血。这些研究表明，链激酶和尿激酶在治疗与阵发性夜间血红蛋白尿相关的腹腔内静脉血栓形成方面都是安全有效的。
