• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

鼻病变中的骨膜蛋白和纤连蛋白：息肉和内翻性乳头状瘤的关键因素

Perıostın and fıbronectın ın nasal lesıons: key players ın polyps and ınverted papıllomas.

作者信息

Birinci Mehmet, Okçu Oğuzhan, Yemiş Tuğba, Gül Oğuz, Terzi Suat, Çeliker Metin, Çelebi Erdivanlı Özlem, Mercantepe Tolga, Tümkaya Levent, Erdivanlı Başar, Dursun Engin

机构信息

Recep Tayyip Erdogan University Faculty of Medicine Department of Otorhinolaryngology Rize Turkey.

Recep Tayyip Erdogan University Faculty of Medicine Department of Pathology Rize Turkey.

出版信息

Colomb Med (Cali). 2024 Dec 30;55(4):e2026411. doi: 10.25100/cm.v55i4.6411. eCollection 2024 Oct-Dec.

DOI:10.25100/cm.v55i4.6411
PMID:40376032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12080358/
Abstract

BACKGROUND

Sinonasal lesions are common benign masses with overlapping clinical and histopathological features. Extracellular matrix proteins such as periostin, fibronectin, and tenascin-C play key roles in tissue remodeling and inflammation, yet their distinct expression profiles in these lesions remain poorly defined.

AIM

This study aimed to compare the immunohistochemical staining patterns of periostin, fibronectin, and tenascin-C in sinonasal lesions to elucidate their roles in pathogenesis and enhance differential diagnosis.

METHODS

In this retrospective study, pathological specimens from 70 patients who underwent surgery for sinonasal polyps were analyzed. Immunohistochemical expression of periostin, fibronectin, and tenascin-C was assessed separately in epithelial and stromal compartments using a semi-quantitative scoring system. Associations between staining patterns and lesion types were evaluated using multinomial logistic regression.

RESULTS

The cohort had a male-to-female ratio of 5:2 with a mean age of approximately 40 years. Nasal polyps demonstrated significantly higher stromal periostin staining compared to both antrochoanal polyps and inverted papillomas. Conversely, antrochoanal polyps exhibited significantly elevated epithelial periostin expression relative to inverted papillomas. Fibronectin expression was markedly increased in nasal polyps, especially in the stroma, supporting its role in inflammatory tissue remodeling. Tenascin-C expression did not differ significantly among the lesion types.

CONCLUSION

Differential expression of periostin and fibronectin suggests distinct pathogenic mechanisms in sinonasal lesions. The compartment-specific staining patterns of periostin, along with the prominent fibronectin expression in nasal polyps, suggest these biomarkers could serve as valuable diagnostic tools and potential therapeutic targets. Further research is needed to explore these pathways in sinonasal disease management.

摘要

背景

鼻窦病变是常见的良性肿物，具有重叠的临床和组织病理学特征。细胞外基质蛋白，如骨膜蛋白、纤连蛋白和腱生蛋白-C在组织重塑和炎症中起关键作用，然而它们在这些病变中的不同表达谱仍不清楚。

目的

本研究旨在比较骨膜蛋白、纤连蛋白和腱生蛋白-C在鼻窦病变中的免疫组化染色模式，以阐明它们在发病机制中的作用并加强鉴别诊断。

方法

在这项回顾性研究中，分析了70例接受鼻窦息肉手术患者的病理标本。使用半定量评分系统分别评估上皮和基质成分中骨膜蛋白、纤连蛋白和腱生蛋白-C的免疫组化表达。使用多项逻辑回归评估染色模式与病变类型之间的关联。

结果

该队列的男女比例为5:2，平均年龄约40岁。与鼻后孔息肉和内翻性乳头状瘤相比，鼻息肉的基质骨膜蛋白染色显著更高。相反，相对于内翻性乳头状瘤，鼻后孔息肉的上皮骨膜蛋白表达显著升高。纤连蛋白表达在鼻息肉中明显增加，尤其是在基质中，支持其在炎症组织重塑中的作用。腱生蛋白-C表达在病变类型之间没有显著差异。

结论

骨膜蛋白和纤连蛋白的差异表达表明鼻窦病变中有不同的致病机制。骨膜蛋白的区域特异性染色模式，以及鼻息肉中显著的纤连蛋白表达，表明这些生物标志物可作为有价值的诊断工具和潜在的治疗靶点。需要进一步研究以探索鼻窦疾病管理中的这些途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/a616df9ee504/1657-9534-cm-55-04-e2026411-gf16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/1568b42cf04c/1657-9534-cm-55-04-e2026411-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/d1fa2a2c90f8/1657-9534-cm-55-04-e2026411-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/7a31a65bd3b7/1657-9534-cm-55-04-e2026411-gf3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/bffce97d718a/1657-9534-cm-55-04-e2026411-gf4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/65e53a6e36bf/1657-9534-cm-55-04-e2026411-gf5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/dfdba9865046/1657-9534-cm-55-04-e2026411-gf6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/a04ef1a68ee0/1657-9534-cm-55-04-e2026411-gf7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/a616df9ee504/1657-9534-cm-55-04-e2026411-gf8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/1568b42cf04c/1657-9534-cm-55-04-e2026411-gf9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/d1fa2a2c90f8/1657-9534-cm-55-04-e2026411-gf10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/7a31a65bd3b7/1657-9534-cm-55-04-e2026411-gf11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/bffce97d718a/1657-9534-cm-55-04-e2026411-gf12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/65e53a6e36bf/1657-9534-cm-55-04-e2026411-gf13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/dfdba9865046/1657-9534-cm-55-04-e2026411-gf14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/a04ef1a68ee0/1657-9534-cm-55-04-e2026411-gf15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/a616df9ee504/1657-9534-cm-55-04-e2026411-gf16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/1568b42cf04c/1657-9534-cm-55-04-e2026411-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/d1fa2a2c90f8/1657-9534-cm-55-04-e2026411-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/7a31a65bd3b7/1657-9534-cm-55-04-e2026411-gf3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/bffce97d718a/1657-9534-cm-55-04-e2026411-gf4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/65e53a6e36bf/1657-9534-cm-55-04-e2026411-gf5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/dfdba9865046/1657-9534-cm-55-04-e2026411-gf6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/a04ef1a68ee0/1657-9534-cm-55-04-e2026411-gf7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/a616df9ee504/1657-9534-cm-55-04-e2026411-gf8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/1568b42cf04c/1657-9534-cm-55-04-e2026411-gf9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/d1fa2a2c90f8/1657-9534-cm-55-04-e2026411-gf10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/7a31a65bd3b7/1657-9534-cm-55-04-e2026411-gf11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/bffce97d718a/1657-9534-cm-55-04-e2026411-gf12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/65e53a6e36bf/1657-9534-cm-55-04-e2026411-gf13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/dfdba9865046/1657-9534-cm-55-04-e2026411-gf14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/a04ef1a68ee0/1657-9534-cm-55-04-e2026411-gf15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f1/12080358/a616df9ee504/1657-9534-cm-55-04-e2026411-gf16.jpg

相似文献

1
Perıostın and fıbronectın ın nasal lesıons: key players ın polyps and ınverted papıllomas.鼻病变中的骨膜蛋白和纤连蛋白：息肉和内翻性乳头状瘤的关键因素
Colomb Med (Cali). 2024 Dec 30;55(4):e2026411. doi: 10.25100/cm.v55i4.6411. eCollection 2024 Oct-Dec.
2
Distinctive expression profiles of Caveolin-1 and Notch-1 protein in patients with nasal polyps or sinonasal inverted papillomas.鼻息肉或鼻窦内翻性乳头状瘤患者中Caveolin-1和Notch-1蛋白的独特表达谱。
Pathol Res Pract. 2018 Dec;214(12):2004-2010. doi: 10.1016/j.prp.2018.09.029. Epub 2018 Sep 29.
3
Nasal contact endoscopy for the in vivo diagnosis of inverted schneiderian papilloma and unilateral inflammatory nasal polyps.鼻接触性内镜用于内翻性施耐德乳头状瘤和单侧炎性鼻息肉的活体诊断
Am J Rhinol. 2007 Mar-Apr;21(2):137-44. doi: 10.2500/ajr.2007.21.3003.
4
Human topoisomerase II-alpha is highly expressed in sinonasal-inverted papilloma, but not in inflammatory polyp.人拓扑异构酶II-α在鼻窦内翻性乳头状瘤中高表达，但在炎性息肉中不表达。
J Cell Mol Med. 2008 Sep-Oct;12(5A):1551-8. doi: 10.1111/j.1582-4934.2008.00381.x. Epub 2008 Jun 9.
5
Incidence of neoplasia in patients with clinically suspicious nasal lesions and the value of computed tomography imaging in diagnosis.临床可疑鼻部病变患者的肿瘤发生率及计算机断层扫描成像在诊断中的价值。
J Laryngol Otol. 2015 Mar;129(3):254-60. doi: 10.1017/S0022215115000213. Epub 2015 Feb 16.
6
CD163 Immunohistochemical "Circle Sign" Staining Pattern Differentiates Sinonasal Papillomas From Morphologically Similar Non-neoplastic Lesions.CD163 免疫组化“圆圈信号”染色模式可区分鼻腔鼻窦乳头状瘤与形态学相似的非肿瘤性病变。
Am J Surg Pathol. 2022 Nov 1;46(11):1507-1513. doi: 10.1097/PAS.0000000000001953. Epub 2022 Aug 23.
7
[Clinical analysis of nasal inverted papilloma complicated with nasal polyp].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Sep;26(17):781-2.
8
[Inverted sinonasal papillomas. Review of 61 cases].[鼻窦内翻性乳头状瘤。61例病例回顾]
Acta Otorrinolaringol Esp. 2009 Nov-Dec;60(6):402-8. doi: 10.1016/j.otorri.2009.05.002. Epub 2009 Aug 15.
9
Involvement of the extracellular matrix proteins periostin and tenascin C in nasal polyp remodeling by regulating the expression of MMPs.细胞外基质蛋白骨膜蛋白和腱生蛋白C通过调节基质金属蛋白酶的表达参与鼻息肉重塑。
Clin Transl Allergy. 2021 Sep 6;11(7):e12059. doi: 10.1002/clt2.12059. eCollection 2021 Aug.
10
Differential expression of periostin in the nasal polyp may represent distinct histological features of chronic rhinosinusitis.骨膜蛋白在鼻息肉中的差异表达可能代表慢性鼻-鼻窦炎的不同组织学特征。
Auris Nasus Larynx. 2015 Apr;42(2):123-7. doi: 10.1016/j.anl.2014.09.003. Epub 2014 Sep 27.

本文引用的文献

1
Serum and Tissue Periostin Expression in Unilateral Benign Lesions of the Nose and the Paranasal Sinuses.血清和组织骨膜蛋白在单侧鼻及鼻窦良性病变中的表达
J Pers Med. 2024 Dec 19;14(12):1156. doi: 10.3390/jpm14121156.
2
Inflammatory Profile of Antrochoanal Polyps in the Caucasian Population - A Histologic Study.高加索人群中鼻后息肉的炎症特征-一项组织学研究。
Am J Rhinol Allergy. 2021 Sep;35(5):664-673. doi: 10.1177/1945892421990529. Epub 2021 Feb 5.
3
Differential Expression of Extracellular Matrix Components in Nasal Polyp Endotypes.
鼻息肉内表型中外细胞基质成分的差异表达。
Am J Rhinol Allergy. 2019 Nov;33(6):665-670. doi: 10.1177/1945892419860634. Epub 2019 Jun 25.
4
Tenascin C, Fibronectin, and Tumor-Stroma Ratio in Pancreatic Ductal Adenocarcinoma.胰腺癌中肌腱蛋白C、纤连蛋白与肿瘤-基质比值
Pancreas. 2019 Jan;48(1):43-48. doi: 10.1097/MPA.0000000000001195.
5
Periostin as a Biomarker for Nasal Polyps in Chronic Rhinosinusitis.骨膜蛋白作为慢性鼻-鼻窦炎鼻息肉的生物标志物。
Otolaryngol Head Neck Surg. 2018 Jan;158(1):181-186. doi: 10.1177/0194599817737967. Epub 2017 Oct 17.
6
Immunohistochemical Study EMT-Related Proteins in HPV-, and EBV-Negative Patients with Sinonasal Tumours.人乳头瘤病毒和EB病毒阴性鼻窦肿瘤患者中上皮-间质转化相关蛋白的免疫组织化学研究
Pathol Oncol Res. 2016 Oct;22(4):781-8. doi: 10.1007/s12253-016-0068-3. Epub 2016 Apr 30.
7
Sinonasal inverted papilloma: From diagnosis to treatment.鼻窦内翻性乳头状瘤：从诊断到治疗
Eur Ann Otorhinolaryngol Head Neck Dis. 2016 Nov;133(5):337-341. doi: 10.1016/j.anorl.2016.03.006. Epub 2016 Apr 1.
8
Association of periostin expression with eosinophilic inflammation in nasal polyps.骨膜蛋白表达与鼻息肉中嗜酸性粒细胞炎症的关联。
J Allergy Clin Immunol. 2015 Dec;136(6):1700-1703.e9. doi: 10.1016/j.jaci.2015.09.005. Epub 2015 Oct 29.
9
Cytokines in Chronic Rhinosinusitis. Role in Eosinophilia and Aspirin-exacerbated Respiratory Disease.慢性鼻-鼻窦炎中的细胞因子。在嗜酸性粒细胞增多和阿司匹林诱发的呼吸道疾病中的作用。
Am J Respir Crit Care Med. 2015 Sep 15;192(6):682-94. doi: 10.1164/rccm.201412-2278OC.
10
Fascin expression in cholesteatoma: correlation with destruction of the ossicular chain and extent of disease.胆脂瘤中Fascin的表达：与听小骨链破坏及疾病范围的相关性。
Clin Otolaryngol. 2015 Aug;40(4):335-40. doi: 10.1111/coa.12373.