Romano Fabrizio Ricci, Voegels Richard Louis, Goto Elder Yoshimitsu, Prado Flavio Augusto Passarelli, Butugan Ossamu
Department of Otorhinolaryngology, University of São Paulo-Medical School, São Paulo, SP, Brazil.
Am J Rhinol. 2007 Mar-Apr;21(2):137-44. doi: 10.2500/ajr.2007.21.3003.
Inverted schneiderian papilloma is an entity surrounded by controversies ranging from its etiology to the indication of treatment. Any method that permits histopathological analysis without damage to the tissue studied deserves to be investigated. In this study, we tested a new noninvasive method, i.e., nasal contact endoscopy.
The main alterations visible on nasal contact endoscopy were described in 11 patients with inverted papilloma and in 8 patients with unilateral inflammatory nasal polyps. The characteristics showing the differentiation between the two entities were defined and these findings were presented to inexperienced examiners.
The significant characteristics for differentiation between the two diseases were the presence of vacuolized cells, cellular heterogeneity, cell clusters, a ciliated respiratory epithelium, and vascular patterns. Two of the three examiners showed a statistically significant high rate of correct diagnosis.
Nasal contact endoscopy may be an effective method for the differential diagnosis between inverted schneiderian papilloma and inflammatory polyps even when the examiner is inexperienced.
内翻性乳头状瘤是一个充满争议的疾病，从其病因到治疗指征均存在争议。任何能够在不损伤所研究组织的情况下进行组织病理学分析的方法都值得研究。在本研究中，我们测试了一种新的非侵入性方法，即鼻接触式内镜检查。
描述了11例内翻性乳头状瘤患者和8例单侧炎性鼻息肉患者在鼻接触式内镜检查中可见的主要改变。定义了显示这两种疾病差异的特征，并将这些发现呈现给经验不足的检查者。
两种疾病鉴别的显著特征为空泡化细胞、细胞异质性、细胞簇、纤毛呼吸上皮和血管形态。三名检查者中有两名显示出统计学上显著的高正确诊断率。
即使检查者经验不足，鼻接触式内镜检查也可能是鉴别内翻性乳头状瘤和炎性息肉的有效方法。
