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口腔局限性淀粉样变性：一种罕见的临床病症。

Localized Amyloidosis of the Oral Cavity: A Rare Clinical Entity.

作者信息

Maloney Brian, Fisher Veronica, Healy Claire M

机构信息

National Maxillofacial Unit St. James's Hospital Dublin Ireland.

Division of Oral and Maxillofacial Surgery, Medicine, Pathology and Radiology Dublin Dental University Hospital, Trinity College Dublin Ireland.

出版信息

Clin Case Rep. 2025 May 15;13(5):e70413. doi: 10.1002/ccr3.70413. eCollection 2025 May.

DOI:10.1002/ccr3.70413
PMID:40376202
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12079365/
Abstract

Amyloidosis is a complex disease which rarely affects the oral cavity. While localized and systemic variants have a similar clinical presentation, these entities differ vastly in their natural history and prognosis. There is a need for practitioners to be aware of the diverse presentation of this disease and the need for further workup. We present two cases of localised oral amyloidosis, outline their investigation and management and review the related literature.

摘要

淀粉样变性是一种复杂的疾病，很少累及口腔。虽然局限性和全身性变体有相似的临床表现，但这些实体在其自然病程和预后方面有很大差异。从业者有必要了解这种疾病的多样表现以及进一步检查的必要性。我们报告两例局限性口腔淀粉样变性病例，概述其检查和处理过程，并复习相关文献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4b3/12079365/7d7cce56ca38/CCR3-13-e70413-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4b3/12079365/834295a62450/CCR3-13-e70413-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4b3/12079365/cb250bb3741b/CCR3-13-e70413-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4b3/12079365/ac0ff506effc/CCR3-13-e70413-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4b3/12079365/f5caa41f35b3/CCR3-13-e70413-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4b3/12079365/7d7cce56ca38/CCR3-13-e70413-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4b3/12079365/834295a62450/CCR3-13-e70413-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4b3/12079365/cb250bb3741b/CCR3-13-e70413-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4b3/12079365/ac0ff506effc/CCR3-13-e70413-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4b3/12079365/f5caa41f35b3/CCR3-13-e70413-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4b3/12079365/7d7cce56ca38/CCR3-13-e70413-g001.jpg

相似文献

1
Localized Amyloidosis of the Oral Cavity: A Rare Clinical Entity.口腔局限性淀粉样变性：一种罕见的临床病症。
Clin Case Rep. 2025 May 15;13(5):e70413. doi: 10.1002/ccr3.70413. eCollection 2025 May.
2
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本文引用的文献

1
Oral manifestations of amyloidosis and the diagnostic applicability of oral tissue biopsy.淀粉样变的口腔表现及口腔组织活检的诊断应用。
J Oral Pathol Med. 2024 Jan;53(1):61-69. doi: 10.1111/jop.13504. Epub 2023 Dec 28.
2
Oral amyloidosis: an update.口腔淀粉样变：更新。
Med Oral Patol Oral Cir Bucal. 2023 Jul 1;28(4):e341-e346. doi: 10.4317/medoral.25761.
3
Amyloid nomenclature 2022: update, novel proteins, and recommendations by the International Society of Amyloidosis (ISA) Nomenclature Committee.淀粉样变命名 2022：更新、新型蛋白质以及国际淀粉样变性学会（ISA）命名委员会的建议。
Amyloid. 2022 Dec;29(4):213-219. doi: 10.1080/13506129.2022.2147636. Epub 2022 Nov 24.
4
Immunoglobulin light chain amyloidosis diagnosis and treatment algorithm 2021.2021 年免疫球蛋白轻链淀粉样变的诊断和治疗算法。
Blood Cancer J. 2021 May 15;11(5):90. doi: 10.1038/s41408-021-00483-7.
5
Localized Amyloidosis Involving Palatine Tonsils: A Case Report and Literature Review.局部淀粉样变累及腭扁桃体：病例报告及文献复习。
Head Neck Pathol. 2020 Dec;14(4):1036-1040. doi: 10.1007/s12105-020-01177-5. Epub 2020 May 25.
6
Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee.淀粉样变命名 2018：国际淀粉样变学会（ISA）命名委员会的建议。
Amyloid. 2018 Dec;25(4):215-219. doi: 10.1080/13506129.2018.1549825. Epub 2019 Jan 7.
7
Systemic immunoglobulin light chain amyloidosis.系统性免疫球蛋白轻链淀粉样变性。
Nat Rev Dis Primers. 2018 Oct 25;4(1):38. doi: 10.1038/s41572-018-0034-3.
8
Oral amyloidosis: A strategy to differentiate systemic amyloidosis involving the oral cavity and localized amyloidosis.口腔淀粉样变：一种区分累及口腔的系统性淀粉样变和局限性淀粉样变的策略。
Oral Dis. 2019 Apr;25(3):670-675. doi: 10.1111/odi.12870. Epub 2018 Jun 7.
9
Localized Nasopharyngeal Amyloidosis: A Clinicopathologic Series of 7 Cases with a Literature Review.局限性鼻咽部淀粉样变性：7例临床病理系列报道并文献复习
Head Neck Pathol. 2018 Dec;12(4):542-547. doi: 10.1007/s12105-017-0880-4. Epub 2017 Dec 27.
10
AL amyloidosis: from molecular mechanisms to targeted therapies.AL 型淀粉样变性：从分子机制到靶向治疗。
Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):1-12. doi: 10.1182/asheducation-2017.1.1.