口腔淀粉样变：更新。
Oral amyloidosis: an update.
机构信息
Department of Oral Pathology João de Barros Barreto University Hospital Mundurucus Street, nº 4487, Zip Code 66073-000, Guamá Belém, Pará, Brazil
出版信息
Med Oral Patol Oral Cir Bucal. 2023 Jul 1;28(4):e341-e346. doi: 10.4317/medoral.25761.
BACKGROUND
Amyloidosis is a disease characterized by the progressive deposition of abnormal proteins that can occur in any organ. In the oral cavity, the tongue is the most common affected site, usually causing macroglossia. Biopsy is essential for the diagnosis and the occurrence of its systemic form is mandatory to be investigated. This systematic review evaluated the existing information in the literature on Amyloidosis in the oral cavity to allow a more comprehensive and updated analysis of its clinicopathological characteristics, as well as to explore the main forms of treatment and prognostic factors.
MATERIAL AND METHODS
Electronic searches were undertaken in five databases supplemented by manual scrutiny.
RESULTS
A total of 111 studies were included with 158 individuals.
CONCLUSIONS
The disease had a higher prevalence in women, the tongue was the most affected site, as well as the systemic form of the disease. The worst prognosis was for cases of systemic amyloidosis associated with multiple myeloma.
背景
淀粉样变性是一种以异常蛋白进行性沉积为特征的疾病，可发生于任何器官。在口腔中，舌是最常受累的部位，通常导致巨舌症。活检对于诊断至关重要，必须对其系统性形式进行调查。本系统评价评估了口腔淀粉样变性的现有文献信息，以便更全面和更新地分析其临床病理特征，并探讨主要的治疗方法和预后因素。
材料和方法
在五个数据库中进行电子检索，并辅以手动审查。
结果
共纳入 111 项研究，涉及 158 例个体。
结论
该疾病在女性中更为常见，舌是最常受累的部位，以及系统性疾病形式。与多发性骨髓瘤相关的系统性淀粉样变性预后最差。
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