Wang Yang, Tu Meijie, Gao Huihui, Deng Shuli
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, China.
Stem Cells Int. 2025 May 8;2025:8338337. doi: 10.1155/sci/8338337. eCollection 2025.
Dental stem cells are widely viewed as good options for bone regeneration because of their ease of acquisition, innate ability to renew themselves, and ability to differentiate into different types of cells. However, the process of osteogenic differentiation of dental stem cells is orchestrated by an intricate system of regulatory mechanisms. Recent studies have demonstrated the critical impacts of circular RNAs (circRNAs) on osteogenic differentiation of dental stem cells. Exploring the roles and regulatory pathways of circRNAs in dental stem cells could identify novel targets and approaches for utilizing dental stem cell therapy in clinical settings. This review provides a comprehensive overview of the functions and mechanisms of circRNAs, with a particular focus on their expression patterns and regulatory roles in osteogenic differentiation of various dental stem cell types. Furthermore, this review discusses current research challenges in this field and proposes future directions for advancing our understanding of circRNA-mediated regulation in dental stem cell biology.
由于牙干细胞易于获取、具有自我更新的内在能力以及能够分化为不同类型的细胞，它们被广泛视为骨再生的良好选择。然而，牙干细胞的成骨分化过程是由一个复杂的调控机制系统精心安排的。最近的研究表明，环状RNA（circRNAs）对牙干细胞的成骨分化具有关键影响。探索circRNAs在牙干细胞中的作用和调控途径，可能会确定在临床环境中利用牙干细胞治疗的新靶点和新方法。本综述全面概述了circRNAs的功能和机制，特别关注它们在各种牙干细胞类型成骨分化中的表达模式和调控作用。此外，本综述讨论了该领域当前的研究挑战，并提出了未来的发展方向，以促进我们对牙干细胞生物学中circRNA介导的调控的理解。
