Saito Mizuki, Shimazaki Yoshihiro, Yoshii Saori, Kojima Tetsuhito
Preventive Dentistry and Dental Public Health, Aichi Gakuin University School of Dentistry, Nagoya, JPN.
Dental Department, Aichi Health Promotion Foundation, Nagoya, JPN.
Cureus. 2025 Apr 14;17(4):e82266. doi: 10.7759/cureus.82266. eCollection 2025 Apr.
This study used health-examination data from a large population to examine the association between ABO blood type and periodontitis, considering the influence of confounding factors.
The study analyzed 2,311 individuals who underwent health examinations, including oral health examinations and blood-type tests. The Community Periodontal Index was used to evaluate periodontal status. Logistic regression analysis was performed with severe periodontitis as the dependent variable and blood type and other variables as independent variables; odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. The sex differences in the associations between severe periodontitis and either blood type or the presence or absence of blood-type antigens (A or B antigens) were also examined.
There were 879 (38.0%), 500 (21.6%), 234 (10.1%), and 698 (30.2%) participants with blood types A, B, AB, and O, respectively. Individuals with blood types A and AB had significantly higher ORs for severe periodontitis compared to those who had blood type B (OR 1.45 [95% CI 1.01-2.08] and 1.88 [95% CI 1.17-3.01], respectively). The association between blood type and severe periodontitis was significant only in men. In the association between blood-type antigen status and severe periodontitis, those with blood type A or AB who had the A antigen had a significantly higher OR for severe periodontitis than those with blood type B or O who did not have the A antigen (OR 1.40, 95% CI 1.09-1.80).
Individuals with blood types A and AB tended to have a higher prevalence of periodontitis. Future studies should consider the potential influence of blood type on periodontal status.
本研究利用来自大量人群的健康检查数据，在考虑混杂因素影响的情况下，研究ABO血型与牙周炎之间的关联。
该研究分析了2311名接受健康检查的个体，包括口腔健康检查和血型检测。采用社区牙周指数评估牙周状况。以重度牙周炎为因变量，血型及其他变量为自变量进行逻辑回归分析；计算比值比（OR）和95%置信区间（CI）。还研究了重度牙周炎与血型或血型抗原（A或B抗原）的存在与否之间关联的性别差异。
分别有879名（38.0%）、500名（21.6%）、234名（10.1%）和698名（30.2%）参与者的血型为A、B、AB和O型。与B型血个体相比，A型和AB型血个体患重度牙周炎的OR值显著更高（分别为OR 1.45 [95% CI 1.01 - 2.08]和1.88 [95% CI 1.17 - 3.01]）。血型与重度牙周炎之间的关联仅在男性中显著。在血型抗原状态与重度牙周炎的关联中，具有A抗原的A型或AB型血个体患重度牙周炎的OR值显著高于不具有A抗原的B型或O型血个体（OR 1.40，95% CI 1.09 - 1.80）。
A型和AB型血个体患牙周炎的患病率往往较高。未来的研究应考虑血型对牙周状况的潜在影响。
