Wang Shuxun, Ding Wei, Lu Shenning, Li Linjia, Qian Furong, Chen Canhui, Liu Longsheng, Cai Yongtong, Liu Xian, Perez Sandra, Frutos Roger, Yao Hangping, Zhou Yuhang, Ye Chunsheng, Wu Danna, Li Shizhu, Kwete Xiaoxiao Jiang, Sui Yuan, Wang Duoquan
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Shanghai, China.
Université Côte d'Azur, ESPACE UMR 7300, Nice, France.
China CDC Wkly. 2025 May 2;7(18):635-643. doi: 10.46234/ccdcw2025.105.
Malaria remains a major global health challenge. Understanding the research progress of the potential innovative tools is important for malaria elimination. This scoping review aims to explore China's research and development (R&D) advances from 2013-2023 in addressing the current challenges and contributing to global malaria elimination. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR), this review searched the English and Simplified Chinese data sources from five databases. A total of 11,112 English articles and 2,944 Chinese articles were retrieved. After screening, 44 English and 13 Chinese articles were included. Key advancements were identified in three domains: vector control, pathogen screening and diagnosis, and prevention and treatment. Innovations in vector control include studies such as the use of strains and symbiont-mediated RNAi approaches to block malaria transmission. Advances in pathogen screening and diagnosis feature biosensor development, AI monitoring technologies, and novel amplification gene and nucleic acid detection technologies. In prevention and treatment, artemisinin-based combination therapies (ACTs) remain a cornerstone, with additional progress in industrial pharmaceuticals and technologies already in field and semi-field-testing stages. This review underscores the importance of leveraging China's R&D capacity to meet global challenges. To maximize impact, we call for global attention to strengthening international collaboration with China in malaria R&D to accelerate the commercialization, regulatory approval, and large-scale deployment of innovations.
疟疾仍然是一项重大的全球卫生挑战。了解潜在创新工具的研究进展对于消除疟疾至关重要。本范围综述旨在探讨中国在2013年至2023年期间在应对当前挑战及推动全球疟疾消除方面的研发进展。本综述采用系统评价和Meta分析扩展版的范围综述首选报告项目（PRISMA-ScR），从五个数据库中检索了英文和简体中文数据源。共检索到11,112篇英文文章和2,944篇中文文章。经过筛选，纳入了44篇英文文章和13篇中文文章。在三个领域确定了关键进展：病媒控制、病原体筛查与诊断以及预防与治疗。病媒控制方面的创新包括使用品系和共生菌介导的RNA干扰方法来阻断疟疾传播等研究。病原体筛查与诊断方面的进展包括生物传感器开发、人工智能监测技术以及新型扩增基因和核酸检测技术。在预防与治疗方面，以青蒿素为基础的联合疗法（ACTs）仍然是基石，在工业制药以及已处于现场和半现场测试阶段的技术方面也取得了进一步进展。本综述强调了利用中国的研发能力应对全球挑战的重要性。为了最大限度地发挥影响，我们呼吁全球关注加强与中国在疟疾研发方面的国际合作，以加速创新成果的商业化、监管审批和大规模推广。
