Khanam Aaliya, Raj Rajnish, Wani Zaid A, Rather Yasir H, Arshad Iqra
Department of Psychiatry, Institute of Mental Health and Neurosciences Kashmir, Government Medical College, Srinagar, Jammu and Kashmir, India.
Ind Psychiatry J. 2025 Jan-Apr;34(1):114-116. doi: 10.4103/ipj.ipj_474_24. Epub 2025 Apr 18.
Pregabalin, a gamma-aminobutyric acid (GABA) analog, is a new-generation antiepileptic that is approved for the treatment of neuropathic pain, fibromyalgia, partial seizures, and generalized anxiety disorder. There is a rising concern regarding its abuse potential, and a handful of case reports have highlighted the same. We present a case series on pregabalin dependence. In contrast to previous case reports, which focused on patients with a history of illicit drug abuse, we present cases of drug-naïve individuals for whom pregabalin was the first substance of abuse. The highlight of the study is that we describe cases of pregabalin intoxication and a rare case of pregabalin withdrawal, which presented as a lethal suicidal attempt to liaison psychiatric settings.
普瑞巴林是一种γ-氨基丁酸（GABA）类似物，是新一代抗癫痫药物，已被批准用于治疗神经性疼痛、纤维肌痛、部分性癫痫发作和广泛性焦虑症。人们对其滥用潜力的担忧日益增加，一些病例报告也凸显了这一点。我们呈现了一组关于普瑞巴林依赖的病例系列。与之前专注于有非法药物滥用史患者的病例报告不同，我们呈现的是初次使用药物个体的病例，对他们来说普瑞巴林是第一种滥用物质。该研究的亮点在于我们描述了普瑞巴林中毒的病例以及一例罕见的普瑞巴林戒断病例，后者表现为在联络精神科时出现致命的自杀企图。
