Raj Rajnish, Dar Shabir Ahmad, Wani Zaid Ahmad, Khare Vaibhav Kumar, Haq Inaamul
Department of Psychiatry, Institute of Mental Health and Neurosciences Kashmir, Government Medical College, Srinagar, Jammu and Kashmir, India.
Department of Community Medicine, Government Medical College, Srinagar, Jammu and Kashmir, India.
Ind Psychiatry J. 2025 Jan-Apr;34(1):108-113. doi: 10.4103/ipj.ipj_6_25. Epub 2025 Apr 18.
Studies have hypothesized the role of the immune-inflammatory process behind the pathophysiology of psychiatric disorders like schizophrenia. Antipsychotic medication has been shown to suppress inflammatory response via complex mechanisms alleviating psychiatric symptoms.
To assess the relation of neutrophil-to-lymphocyte ratio (NLR) with antipsychotic administration and clinical symptomatology severity.
A longitudinal study was performed among 34 inpatients who fulfilled inclusion and exclusion criteria. Sociodemographic details were collected, and the brief psychiatric rating scale (BPRS) was applied during admission. Blood sampling was performed during baseline and at discharge for the NLR ratio (neutrophil count/lymphocyte count) with the application of BPRS.
The mean ± SD age of the population was 38.91 ± 11.44 years, with male gender predominance (N = 25, 73.5%). The median duration of illness and duration of treatment were 10 months and 40 days, respectively. Twelve (35.3%) subjects were antipsychotic naïve. The mean ± SD of BPRS and NLR during admission was 49.94 ± 5.33 and 2.49 ± 0.92 and during discharge was 26.76 ± 6.04 and 2.08 ± 0.72, respectively.
The results confirmed the NLR-lowering effect of antipsychotics alongside lowering of clinical symptomatology. NLR has the potential to be a biomarker indicating antipsychotic treatment response.
研究推测免疫炎症过程在精神分裂症等精神障碍的病理生理学中发挥作用。抗精神病药物已被证明可通过复杂机制抑制炎症反应，从而减轻精神症状。
评估中性粒细胞与淋巴细胞比值（NLR）与抗精神病药物使用及临床症状严重程度之间的关系。
对34名符合纳入和排除标准的住院患者进行了一项纵向研究。收集了社会人口学详细信息，并在入院时应用简明精神病评定量表（BPRS）。在基线和出院时采集血液样本，检测NLR比值（中性粒细胞计数/淋巴细胞计数），同时应用BPRS。
研究人群的平均年龄±标准差为38.91±11.44岁，男性占主导（N = 25，73.5%）。疾病的中位病程和治疗时间分别为10个月和40天。12名（35.3%）受试者未使用过抗精神病药物。入院时BPRS和NLR的平均±标准差分别为49.94±5.33和2.49±0.92，出院时分别为为26.76±6.04和2.08±0.72。
结果证实了抗精神病药物在降低临床症状的同时具有降低NLR的作用。NLR有可能成为指示抗精神病治疗反应的生物标志物。
