Department of Medicine and Surgery, University of Milano Bicocca, Monza, MB, Italy.
Department of Medicine and Surgery, University of Milano Bicocca, Monza, MB, Italy.
Gen Hosp Psychiatry. 2019 May-Jun;58:7-12. doi: 10.1016/j.genhosppsych.2019.02.003. Epub 2019 Feb 15.
Neutrophil-lymphocyte, monocyte-lymphocyte and platelet-lymphocyte ratio are inexpensive and reproducible biomarkers of inflammation found to be elevated in mood disorders. This study aimed to compare inflammatory ratios between bipolar disorder and major depressive disorder and between bipolar disorder manic episodes and bipolar disorder depressive episodes.
We included 142 Caucasian patients (major depressive disorder: n = 36; bipolar disorder manic episode: n = 66; bipolar disorder depressive episode: n = 40). We measured white blood cells, neutrophils, lymphocytes, monocytes, platelets, glucose, and total cholesterol. Neutrophil-lymphocyte ratio, monocyte-lymphocyte ratio, and platelet-lymphocyte ratio were calculated.
Neutrophil-lymphocyte ratio and monocyte-lymphocyte ratio were significantly higher in bipolar disorder manic episodes when compared to bipolar disorder depressive episodes and major depressive disorder episodes after adjustment for age, sex, body mass index, and smoking.
To our knowledge, our study is the first one to compare inflammatory ratios between different bipolar disorder phases and major depressive disorder episodes. In accord with previous studies on other inflammatory mediators, we found higher neutrophil-lymphocyte and monocyte-lymphocyte ratios in bipolar manic episodes, suggesting that inflammatory changes occur especially during acute episodes of mania.
中性粒细胞-淋巴细胞、单核细胞-淋巴细胞和血小板-淋巴细胞比值是炎症的廉价且可重现的生物标志物，在心境障碍中发现其升高。本研究旨在比较双相障碍和重度抑郁症、双相障碍躁狂发作和双相障碍抑郁发作之间的炎症比值。
我们纳入了 142 名白种人患者（重度抑郁症：n=36；双相障碍躁狂发作：n=66；双相障碍抑郁发作：n=40）。我们测量了白细胞、中性粒细胞、淋巴细胞、单核细胞、血小板、血糖和总胆固醇。计算了中性粒细胞-淋巴细胞比值、单核细胞-淋巴细胞比值和血小板-淋巴细胞比值。
在调整年龄、性别、体重指数和吸烟状况后，与双相障碍抑郁发作和重度抑郁症发作相比，双相障碍躁狂发作时中性粒细胞-淋巴细胞比值和单核细胞-淋巴细胞比值显著升高。
据我们所知，我们的研究是首次比较不同双相障碍阶段和重度抑郁症发作之间的炎症比值。与其他炎症介质的先前研究一致，我们发现在双相躁狂发作中存在更高的中性粒细胞-淋巴细胞和单核细胞-淋巴细胞比值，表明炎症变化尤其发生在急性躁狂发作期间。
