Walburn Tyler, Tuaç Yetkin, Aktan Çağdaş, Argun Okan, Chen Luke W, Yang David D, Moningi Shalini, Leeman Jonathan E, Orio Peter F, Nguyen Paul L, D'Amico Anthony V, Sayan Mutlay
Department of Radiation Oncology, Brigham and Women's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Department of Statistics, Ankara University Faculty of Science, Ankara, Türkiye.
Eurasian J Med. 2025 Apr 21;57(1):1-5. doi: 10.5152/eurasianjmed.2025.25804.
Background: Although extensive research highlights the detrimental effect of cribriform pattern 4 (CP4) on survival in non-high-risk prostate cancer (PC), its prognostic significance in high-risk PC is not well understood. Methods: The individual patient data from the The Cancer Genome Atlas (TCGA) database following radical prostatectomy was retrospectively examined. A predefined statistical analysis was conducted to evaluate the potential association between CP4 and progression-free survival (PFS). Results: Of the 135 patients examined, CP4 was present in 66 (48.9%). Median follow-up was 45.93 months (interquartile range: 22.87, 80.10). Cribriform pattern 4 was associated with a significantly reduced PFS (subdistribution hazard ratio, 1.99; 95% CI, 1.01-3.92; P=.045) following adjustment for covariates. Conclusions: The presence of CP4 in high-risk Gleason 8-10 PC portends worse PFS. Further studies are warranted to fully understand its implications in risk stratification and post-operative management of PC.
尽管大量研究强调筛状模式4（CP4）对非高危前列腺癌（PC）患者生存的不利影响，但其在高危PC中的预后意义尚不清楚。方法：回顾性分析来自癌症基因组图谱（TCGA）数据库中接受根治性前列腺切除术后患者的个体数据。进行了预定义的统计分析，以评估CP4与无进展生存期（PFS）之间的潜在关联。结果：在135例接受检查的患者中，66例（48.9%）存在CP4。中位随访时间为45.93个月（四分位间距：22.87，80.10）。在对协变量进行调整后，筛状模式4与显著降低的PFS相关（亚分布风险比，1.99；95%可信区间，1.01-3.92；P=0.045）。结论：高危Gleason 8-10级PC中CP4的存在预示着更差的PFS。有必要进行进一步研究以充分了解其在PC风险分层和术后管理中的意义。
