Popescu Tudor Cristian Timotei, Stepan Alex Emilian, Florescu Mirela Marinela, Simionescu Cristiana Eugenia
PhD Student, Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania.
Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania.
Curr Health Sci J. 2022 Jan-Mar;48(1):95-101. doi: 10.12865/CHSJ.48.01.14. Epub 2022 Mar 31.
Prostate adenocarcinomas are common lesions with a high incidence and variable prognosis, which can be assessed using tumor grading systems. In this study, we analyzed 329 prostate adenocarcinomas in relation to tumor variants, growth patterns, classical and updated grading systems. The study indicated statistical associations of atrophic, pseudohyperplastic and microcystic variants with low grading scores, the associations of glomeruloid, cribriform with or without necrosis and signet ring-like cell variants with high grading scores, and also of single growth patterns with intermediate scores, which supports the accordance and usefulness of existing grading systems for the identification of aggressive prostate tumor lesions.
前列腺腺癌是常见病变，发病率高且预后各异，可通过肿瘤分级系统进行评估。在本研究中，我们分析了329例前列腺腺癌的肿瘤变异、生长模式、经典和更新的分级系统。研究表明，萎缩性、假增生性和微囊性变异与低分级评分存在统计学关联，肾小球样、伴有或不伴有坏死的筛状以及印戒样细胞变异与高分级评分存在关联，单一生长模式与中等评分存在关联，这支持了现有分级系统在识别侵袭性前列腺肿瘤病变方面的一致性和实用性。
