乙胺丁醇右旋异构体对分枝杆菌属中亚精胺合成的特异性抑制作用。
Specific inhibition of spermidine synthesis in Mycobacteria spp. by the dextro isomer of ethambutol.
作者信息
Paulin L G, Brander E E, Pösö H J
出版信息
Antimicrob Agents Chemother. 1985 Jul;28(1):157-9. doi: 10.1128/AAC.28.1.157.
Abstract
Only the dextro isomer of ethambutol inhibited mycobacterial spermidine synthase and spermidine biosynthesis. Inhibition of mycobacterial spermidine synthase appeared to be specific. Spermidine synthase from Mycobacterium fortuitum, which was resistant to ethambutol in vitro, required a higher concentration of ethambutol for its inhibition than the enzyme of susceptible Mycobacterium bovis.
摘要
仅乙胺丁醇的右旋异构体可抑制分枝杆菌的亚精胺合成酶和亚精胺生物合成。对分枝杆菌亚精胺合成酶的抑制似乎具有特异性。在体外对乙胺丁醇耐药的偶然分枝杆菌的亚精胺合成酶，相较于敏感的牛分枝杆菌的该酶，需要更高浓度的乙胺丁醇才能被抑制。
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