非结核分枝杆菌感染的抗菌药物敏感性试验、耐药机制及治疗。
Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria.
机构信息
Department of Microbiology, The University of Texas Health Science Center at Tyler, USA.
出版信息
Clin Microbiol Rev. 2012 Jul;25(3):545-82. doi: 10.1128/CMR.05030-11.
Abstract
Within the past 10 years, treatment and diagnostic guidelines for nontuberculous mycobacteria have been recommended by the American Thoracic Society (ATS) and the Infectious Diseases Society of America (IDSA). Moreover, the Clinical and Laboratory Standards Institute (CLSI) has published and recently (in 2011) updated recommendations including suggested antimicrobial and susceptibility breakpoints. The CLSI has also recommended the broth microdilution method as the gold standard for laboratories performing antimicrobial susceptibility testing of nontuberculous mycobacteria. This article reviews the laboratory, diagnostic, and treatment guidelines together with established and probable drug resistance mechanisms of the nontuberculous mycobacteria.
摘要
在过去的 10 年中，美国胸科学会（ATS）和美国传染病学会（IDSA）已经推荐了非结核分枝杆菌的治疗和诊断指南。此外，临床和实验室标准协会（CLSI）已经发布并最近（2011 年）更新了建议，包括建议的抗菌药物和药敏临界点。CLSI 还推荐肉汤微量稀释法作为实验室进行非结核分枝杆菌抗菌药物敏感性测试的金标准。本文综述了非结核分枝杆菌的实验室、诊断和治疗指南以及已建立和可能的耐药机制。
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