de Souza Wanderley
Laboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Ilha do Fundão, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho, 373. Cidade Universitária, Rio de Janeiro, RJ, 21941-902, Brazil.
Centro Nacional de Biologia Estrutural e Bioimagens (CENABIO), Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho, 373, Rio de Janeiro, RJ, 21941-902, Brazil.
Acta Parasitol. 2025 May 16;70(3):108. doi: 10.1007/s11686-025-01038-7.
Macromolecules are incorporated by eukaryotic cells through a process known as endocytosis, intensely analyzed in mammalian and yeast cells, but still lacking deep studies in pathogenic protists. Here we present what is presently known on endocytic activity carried out in some members of the Apicomplexa group (mainly concentrated in Plasmodium and Toxoplasma, but with references to Eimeria, Babesia, and Theileria). In most cells, endocytic activity takes place throughout the cell's surface. In apicomplexans, it is restricted to a special surface structure known as a micropore (also called cytostome). Recent studies indicate that several proteins are in the micropore, playing a role in macromolecule uptake from the medium via budding vesicles.
真核细胞通过一种称为内吞作用的过程摄取大分子，这一过程在哺乳动物细胞和酵母细胞中得到了深入分析，但在致病原生生物中仍缺乏深入研究。在这里，我们介绍目前已知的顶复门（Apicomplexa）一些成员（主要集中在疟原虫和弓形虫，但也涉及艾美球虫、巴贝斯虫和泰勒虫）的内吞活性。在大多数细胞中，内吞活性发生在整个细胞表面。在顶复门生物中，它局限于一种特殊的表面结构，称为微孔（也称为胞口）。最近的研究表明，几种蛋白质存在于微孔中，通过出芽小泡在从培养基中摄取大分子的过程中发挥作用。
