Koskimies O, Holmberg C
Arch Dis Child. 1985 Aug;60(8):752-5. doi: 10.1136/adc.60.8.752.
Interstitial nephritis was diagnosed at renal biopsy in 10 previously healthy children. All had identical clinical symptoms: anaemia, raised sedimentation rate, low glomerular filtration rate, protein and leucocytes in the urine, but no bacteria; nine also had glycosuria. Six of the children had a history of recent ingestion of drugs or a serologically proved infection, or both. One child later developed uveitis. After the acute phase all made at least partial recovery, but after a mean follow up of two years and eight months only four were without any signs of disease, three had equivocal findings, two definite renal disease, and one renal failure. Interstitial nephritis, therefore, seems to be a clinical entity often occurring without known cause or triggering factor, its prognosis is variable, and some patients may develop chronic renal failure.
10名既往健康的儿童经肾活检诊断为间质性肾炎。所有患儿均有相同的临床症状：贫血、血沉升高、肾小球滤过率降低、尿中出现蛋白和白细胞，但无细菌；9名患儿还出现糖尿。其中6名儿童近期有药物摄入史或血清学证实的感染史，或两者皆有。1名儿童后来发展为葡萄膜炎。急性期过后，所有患儿至少都有部分恢复，但平均随访两年零八个月后，只有4名患儿无任何疾病迹象，3名患儿检查结果不明确，2名患儿有明确的肾脏疾病，1名患儿出现肾衰竭。因此，间质性肾炎似乎是一种常无已知病因或触发因素而发生的临床病症，其预后不一，部分患者可能发展为慢性肾衰竭。
