肾小管间质性肾炎
Tubulointerstitial Nephritis.
作者信息
Ruebner Rebecca L, Fadrowski Jeffrey J
机构信息
Department of Pediatrics, Division of Nephrology, Johns Hopkins University School of Medicine, 200 North Wolfe Street, Room 3055, Baltimore, MD 21287, USA.
Department of Pediatrics, Division of Nephrology, Johns Hopkins University School of Medicine, 200 North Wolfe Street, Room 3055, Baltimore, MD 21287, USA.
出版信息
Pediatr Clin North Am. 2019 Feb;66(1):111-119. doi: 10.1016/j.pcl.2018.08.009.
Tubulointerstitial nephritis (TIN) is a cause of acute kidney injury in children characterized histologically by an inflammatory cell infiltrate in the kidney interstitium. The most common causes of TIN in children include medications, infections, inflammatory disorders, and genetic conditions. TIN typically presents with nonoliguric acute kidney injury and may be associated with systemic symptoms, including fever, rash, and eosinophilia. The long-term prognosis is generally favorable, with full kidney recovery; however, some patients may develop progressive chronic kidney disease. Immunosuppressive therapy may be indicated for severe or prolonged disease.
肾小管间质性肾炎（TIN）是儿童急性肾损伤的一个病因，其组织学特征为肾间质有炎性细胞浸润。儿童TIN最常见的病因包括药物、感染、炎症性疾病和遗传性疾病。TIN通常表现为非少尿性急性肾损伤，可能伴有全身症状，包括发热、皮疹和嗜酸性粒细胞增多。长期预后一般良好，肾脏可完全恢复；然而，一些患者可能会发展为进行性慢性肾脏病。对于严重或病程迁延的疾病，可能需要进行免疫抑制治疗。
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