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微小RNA及微小RNA靶标分析工具综述

An Overview of miRNA and miRNA Target Analysis Tools.

作者信息

Rakhmetullina Aizhan, Lukasik Anna, Zielenkiewicz Piotr

机构信息

Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.

Department of Plant Molecular Biology, Institute of Experimental Plant Biology and Biotechnology, University of Warsaw, Warsaw, Poland.

出版信息

Methods Mol Biol. 2025;2900:43-71. doi: 10.1007/978-1-0716-4398-3_2.

Abstract

MicroRNA molecules have been shown to play various significant roles in many physiological and pathophysiological processes in living organisms. The tremendous interest in these molecules has led to the significant development and constant release of a number of computational tools useful for basic as well as advanced miRNA-related analyses. These approaches have various constantly evolving utilities, such as detection, target prediction, functional annotation, and many others. In this chapter, we provide an overview of several computational tools useful for broadly defined plant miRNA analysis. We have added to the Tools4miRs new databases that provide extensive information on small noncoding RNA sequences. Additionally, several tools within the platform have been updated, now featuring comprehensive references and accessible links, ensuring users have access to the most recent and relevant research findings.

摘要

微小RNA分子已被证明在生物体的许多生理和病理生理过程中发挥着各种重要作用。对这些分子的极大兴趣导致了许多用于基础以及高级miRNA相关分析的计算工具的显著发展和不断发布。这些方法具有各种不断发展的用途,如检测、靶标预测、功能注释等等。在本章中,我们概述了几种用于广义植物miRNA分析的计算工具。我们已将提供有关小非编码RNA序列广泛信息的新数据库添加到Tools4miRs中。此外,该平台内的几个工具已更新,现在具有全面的参考文献和可访问的链接,确保用户能够获取最新和相关的研究结果。

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