Luna Buitrago Diana, Lovering Ruth C, Caporali Andrea
BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH164TJ, UK.
Functional Gene Annotation, Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK.
Noncoding RNA. 2023 Mar 6;9(2):18. doi: 10.3390/ncrna9020018.
MicroRNAs (miRNAs) are members of the small non-coding RNA family regulating gene expression at the post-transcriptional level. MiRNAs have been found to have critical roles in various biological and pathological processes. Research in this field has significantly progressed, with increased recognition of the importance of miRNA regulation. As a result of the vast data and information available regarding miRNAs, numerous online tools have emerged to address various biological questions related to their function and influence across essential cellular processes. This review includes a brief introduction to available resources for an investigation covering aspects such as miRNA sequences, target prediction/validation, miRNAs associated with disease, pathway analysis and genetic variants within miRNAs.
微小RNA（miRNA）是小非编码RNA家族的成员，在转录后水平调节基因表达。已发现miRNA在各种生物学和病理过程中起关键作用。该领域的研究取得了显著进展，人们对miRNA调节的重要性有了更多认识。由于有大量关于miRNA的数据和信息，出现了许多在线工具来解决与它们在基本细胞过程中的功能和影响相关的各种生物学问题。这篇综述简要介绍了用于研究的可用资源，涵盖miRNA序列、靶标预测/验证、与疾病相关的miRNA、通路分析以及miRNA内的基因变异等方面。
