Lausten Molly A, Boman Bruce M
Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center & Research Institute, Newark, DE 19713, USA.
Department of Biological Sciences, University of Delaware, Newark, DE 19713, USA.
Noncoding RNA. 2023 Jun 7;9(3):34. doi: 10.3390/ncrna9030034.
As advancements in sequencing technology rapidly continue to develop, a new classification of microRNAs has occurred with the discovery of isomiRs, which are relatively common microRNAs with sequence variations compared to their established template microRNAs. This review article seeks to compile all known information about isomiRs in colorectal cancer (CRC), which has not, to our knowledge, been gathered previously to any great extent. A brief overview is given of the history of microRNAs, their implications in colon cancer, the canonical pathway of biogenesis and isomiR classification. This is followed by a comprehensive review of the literature that is available on microRNA isoforms in CRC. The information on isomiRs presented herein shows that isomiRs hold great promise for translation into new diagnostics and therapeutics in clinical medicine.
随着测序技术的进步迅速持续发展，随着异源微小RNA（isomiRs）的发现，出现了一种新的微小RNA分类，与既定的模板微小RNA相比，异源微小RNA是具有序列变异的相对常见的微小RNA。这篇综述文章旨在汇编有关结直肠癌（CRC）中异源微小RNA的所有已知信息，据我们所知，此前尚未在很大程度上收集到这些信息。简要概述了微小RNA的历史、它们在结肠癌中的意义、生物合成的经典途径和异源微小RNA分类。随后对有关CRC中微小RNA异构体的现有文献进行了全面综述。本文提供的有关异源微小RNA的信息表明，异源微小RNA在转化为临床医学中的新诊断方法和治疗方法方面具有巨大潜力。
