Campochiaro P A, Kaden I H, Vidaurri-Leal J, Glaser B M
Arch Ophthalmol. 1985 Mar;103(3):434-6. doi: 10.1001/archopht.1985.01050030130038.
Proliferative vitreoretinopathy (PVR) is the most common cause of failure in retinal reattachment surgery. Giant retinal tears are associated with a particularly high incidence of PVR. It involves the formation of cellular membranes that contract and cause traction retinal detachments. Retinal pigment epithelial (RPE) cells are a major component of these cellular membranes. Displacement of viable RPE cells from their normal position into the vitreous cavity is necessary for membrane formation to occur. This study demonstrates that cryotherapy, but not diathermy, enhances intravitreal dispersion of viable RPE cells in bovine eyes in vitro. This suggests that in some circumstances, excessive cryotherapy may play an exacerbating role in the initiation of PVR.
增殖性玻璃体视网膜病变（PVR）是视网膜复位手术失败的最常见原因。巨大视网膜裂孔与PVR的发生率特别高有关。它涉及细胞膜的形成，这些细胞膜收缩并导致牵引性视网膜脱离。视网膜色素上皮（RPE）细胞是这些细胞膜的主要成分。活的RPE细胞从其正常位置移位到玻璃体腔中是膜形成发生的必要条件。本研究表明，冷冻疗法而非透热疗法可增强体外牛眼中活RPE细胞的玻璃体内扩散。这表明在某些情况下，过度冷冻疗法可能在PVR的起始中起加剧作用。
