Kinetics of enzymes requiring long-chain acyl-CoA esters as substrates: effects of substrate binding to albumin.
作者信息
Bartlett K, Bartlett P, Bartlett N, Sherratt H S
出版信息
Biochem J. 1985 Jul 15;229(2):559-60. doi: 10.1042/bj2290559.
Abstract
摘要
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Kinetics of enzymes requiring long-chain acyl-CoA esters as substrates: effects of substrate binding to albumin.以长链酰基辅酶A酯为底物的酶的动力学：底物与白蛋白结合的影响。
Biochem J. 1985 Jul 15;229(2):559-60. doi: 10.1042/bj2290559.
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Malonyl-CoA binding site and the overt carnitine palmitoyltransferase activity reside on the opposite sides of the outer mitochondrial membrane.丙二酰辅酶A结合位点和明显的肉碱棕榈酰转移酶活性位于线粒体外膜的两侧。
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Effect of a biguanide (buformin) on carnitine palmitoyltransferase activity.
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The malonyl-CoA-long-chain acyl-CoA axis in the maintenance of mammalian cell function.丙二酰辅酶A-长链酰基辅酶A轴在维持哺乳动物细胞功能中的作用
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Influence of diet on the kinetic behavior of hepatic carnitine palmitoyltransferase I toward different acyl CoA esters.饮食对肝脏肉碱棕榈酰转移酶I针对不同酰基辅酶A酯的动力学行为的影响。
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Restoration of the properties of carnitine palmitoyltransferase I in liver mitochondria during re-feeding of starved rats.饥饿大鼠重新进食期间肝脏线粒体中肉碱棕榈酰转移酶I活性的恢复
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Liposomes as carriers of poorly water-soluble substrates: linear modelling of membrane systems with catalytic or binding sites of different facedness. Significance of experimental membrane partition coefficients and of kinetic and equilibrium parameters.脂质体作为难溶性底物的载体：具有不同朝向催化或结合位点的膜系统的线性建模。实验性膜分配系数以及动力学和平衡参数的意义。
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Testing and characterizing enzymes and membrane-bound carrier proteins acting on amphipathic ligands in the presence of bilayer membrane material and soluble binding protein. Application to the uptake of oleate into isolated cells.在存在双层膜材料和可溶性结合蛋白的情况下，对作用于两亲性配体的酶和膜结合载体蛋白进行检测和表征。应用于油酸进入分离细胞的摄取过程。
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本文引用的文献
1
A re-examination of some properties of fatty acyl-CoA micelles.对脂肪酰辅酶A胶束某些性质的重新审视。
J Biol Chem. 1981 Dec 25;256(24):12740-7.
2
Response to starvation of hepatic carnitine palmitoyltransferase activity and its regulation by malonyl-CoA. Sex differences and effects of pregnancy.肝脏肉碱棕榈酰转移酶活性对饥饿的反应及其受丙二酰辅酶A的调节。性别差异及妊娠的影响。
Biochem J. 1982 Dec 15;208(3):673-8. doi: 10.1042/bj2080673.
3
Importance of albumin binding in the assay for carnitine palmitoyltransferase.白蛋白结合在肉碱棕榈酰转移酶测定中的重要性。
Biochem J. 1983 Nov 15;216(2):495-8. doi: 10.1042/bj2160495.
4
Differences in the sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA are due to differences in Ki values.肉碱棕榈酰转移酶对丙二酸单酰辅酶A抑制的敏感性差异是由于Ki值的不同。
J Biol Chem. 1984 Oct 10;259(19):12030-3.
5
Some physical properties of palmityl-coenzyme A micelles.棕榈酰辅酶A胶束的一些物理性质。
Biochim Biophys Acta. 1968 Sep 2;164(1):1-11. doi: 10.1016/0005-2760(68)90065-9.
6
Carnitine palmitoyltransferase I. The site of inhibition of hepatic fatty acid oxidation by malonyl-CoA.肉碱棕榈酰转移酶I。丙二酰辅酶A对肝脏脂肪酸氧化的抑制位点。
J Biol Chem. 1978 Jun 25;253(12):4128-36.
7
Purification and characterization of a long-chain acyl-CoA hydrolase from rat liver microsomes.大鼠肝脏微粒体长链酰基辅酶A水解酶的纯化与特性分析
Biochim Biophys Acta. 1979 Aug 30;574(2):321-33. doi: 10.1016/0005-2760(79)90013-4.
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