甲型H1N1流感病毒神经氨酸酶基因全长DNA拷贝的合成、克隆及一级结构测定

[Synthesis, cloning and determination of the primary structure of a full-size DNA copy of the neuraminidase gene from influenza virus type A subtype H1N1].

作者信息

Beklemishev A B, Blinov V M, Vasilenko S K, Golovin S Ia, Karginov V A

出版信息

Bioorg Khim. 1985 May;11(5):628-35.

Abstract

Complete nucleotide sequence of the cloned full-length DNA copy of the influenza virus A (H1N1) neuraminidase gene has been determined. The predicted amino acid sequence is compared with sequences of neuraminidases from other influenza virus strains. A section of the neuraminidase is found to be homologous to the chicken lysozyme catalytic centre.

摘要

已确定甲型流感病毒（H1N1）神经氨酸酶基因克隆全长DNA拷贝的完整核苷酸序列。将预测的氨基酸序列与其他流感病毒株的神经氨酸酶序列进行比较。发现神经氨酸酶的一部分与鸡溶菌酶催化中心同源。

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