Chaturvedi Shivani, Saxena Sandeep, Kaur Apjit, Kumar Pramod, Pandey Shivani, Mahdi Abbas Ali, Akduman Levent
Department of Ophthalmology, King George's Medical University, Lucknow, India.
Department of Biochemistry, King George's Medical University, Lucknow, India.
Mol Vis. 2025 Mar 28;31:114-125. eCollection 2025.
Serum pro-brain natriuretic peptide (BNP) is a 108-amino-acid prohormone that inhibits vascular endothelial growth factor (VEGF) secretion, protecting pericytes from cell death and decreasing retinal vascularization. The purpose of this study was to investigate the correlation of serum pro-BNP with optical coherence tomography (OCT) indices in diabetic retinopathy.
This cross-sectional study investigated 96 consecutive subjects aged between 40 and 65 years: controls n = 24, no diabetic retinopathy (NoDR) n = 24, non-proliferative diabetic retinopathy (NPDR) n = 24, and proliferative diabetic retinopathy (PDR) n = 24. Same-day analysis of blood samples for serum pro-BNP levels was performed and spectral-domain OCT (SD-OCT) was used to measure the following OCT indices: OCT angiography (OCTA) superficial vessel density (SVD), deep vessel density (DVD), and foveal avascular zone (FAZ); OCT retinal nerve fiber layer (RNFL); and OCT ganglion cell analysis (GCA).
The mean serum pro-BNP levels for the control, NoDR, NPDR, and PDR groups were 14.07 ± 11.51, 27.35 ± 11.81, 280.44 ± 106.13, and 122.33 ± 43.66 pg/ml, respectively. The mean values of the various OCT parameters correlated with serum pro-BNP were OCTA SVD (r = 0.360), OCTA DVD (r = 0.408), OCTA FAZ (r = 0.475), OCT RNFL (r = 0.215) and OCT GCA (r = 0.285; p<0.001).
The serum pro-BNP levels were higher in the NPDR group than in the NoDR group and much lower in the PDR group than in the NPDR group, reflecting a lowering of the protective barrier. These results correlated with the changes in various OCT indices.
血清脑钠肽前体（pro-BNP）是一种由108个氨基酸组成的前激素，它可抑制血管内皮生长因子（VEGF）的分泌，保护周细胞免于细胞死亡并减少视网膜血管生成。本研究旨在探讨血清pro-BNP与糖尿病视网膜病变患者光学相干断层扫描（OCT）指标之间的相关性。
本横断面研究纳入了96例年龄在40至65岁之间的连续受试者：对照组n = 24例，无糖尿病视网膜病变（NoDR）组n = 24例，非增殖性糖尿病视网膜病变（NPDR）组n = 24例，增殖性糖尿病视网膜病变（PDR）组n = 24例。同日对血样进行血清pro-BNP水平分析，并使用光谱域光学相干断层扫描（SD-OCT）测量以下OCT指标：OCT血管造影（OCTA）浅层血管密度（SVD）、深层血管密度（DVD）和黄斑无血管区（FAZ）；OCT视网膜神经纤维层（RNFL）；以及OCT神经节细胞分析（GCA）。
对照组、NoDR组、NPDR组和PDR组的血清pro-BNP平均水平分别为14.07±11.51、27.35±11.81、280.44±106.13和122.33±43.66 pg/ml。与血清pro-BNP相关的各种OCT参数的平均值为：OCTA SVD（r = 0.360）、OCTA DVD（r = 0.408）、OCTA FAZ（r = 0.475）、OCT RNFL（r = 0.215）和OCT GCA（r = 0.285；p<0.001）。
NPDR组血清pro-BNP水平高于NoDR组，而PDR组则远低于NPDR组，这反映了保护屏障的降低。这些结果与各种OCT指标的变化相关。
