Wüster Wolf, Gebbers Pit, Renn Alois, Bütikofer Matthias, Rüdiger Sophie, Riek Roland P, Torres Felix
Zurich University of Applied Sciences (ZHAW), Institute of Applied Mathematics and Physics, Technikumstrasse 9, 8400 Winterthur, Switzerland.
Federal Institute of Technology Zurich (ETHZ), Institute of Molecular Physical Science, Vladimir-Prelog-Weg 2, 8093, Zürich, Switzerland.
Magn Reson (Gott). 2024 May 15;5(1):61-67. doi: 10.5194/mr-5-61-2024. eCollection 2024.
Recent advances in NMR fragment screening use sample illumination to boost NMR sensitivity, reduce measurement time to a few seconds, and reduce sample concentration to a few micromolars. Nevertheless, the absence of a fully automated solution to measure several hundreds of samples with photoinduced hyperpolarization limits the large-scale applicability of the method. We present a setup to couple an optical fiber with a cryogenic probe using the flow-cell accessory port. This setup is compatible with commercially available autosamplers, enabling the fully automated measurement of several hundreds of samples per day.
核磁共振片段筛选的最新进展利用样品光照来提高核磁共振灵敏度，将测量时间缩短至几秒，并将样品浓度降低至几微摩尔。然而，缺乏一种利用光诱导超极化来测量数百个样品的全自动解决方案限制了该方法的大规模应用。我们展示了一种利用流通池附件端口将光纤与低温探头耦合的装置。该装置与市售自动进样器兼容，每天能够全自动测量数百个样品。
