Deng Chunfeng, Hong Lei, Sun Dongni, Miao Hui, Tang Fei, Li Zhaohui, Liu Xi
Department of Nephrology, Longgang Central Hospital of Shenzhen, Shenzhen, 518116, People's Republic of China.
Infect Drug Resist. 2025 May 12;18:2469-2473. doi: 10.2147/IDR.S510660. eCollection 2025.
Mycoplasma hominis (Mh) is a conditional pathogenic microorganism in humans, typically colonizing the genitourinary tract of adults and causing infections in this system. However, Mh is rarely reported as a causative agent of peritoneal dialysis (PD)-associated peritonitis.
A 46-year-old woman undergoing maintenance PD presented with abdominal pain and cloudy PD effluent. Her PD modality is continuous ambulatory peritoneal dialysis (CAPD). Cultures of the PD effluent and blood were negative, and empirical antibiotic therapy was ineffective, leading to a diagnosis of refractory peritonitis. Metagenomic next-generation sequencing (mNGS) detected Mh in the PD effluent. Treatment was adjusted to intraperitoneal (IP) clindamycin combined with intravenous drip(ivdrip) moxifloxacin, resulting in complete recovery.
Patients with culture-negative PD-associated peritonitis or refractory peritonitis should be evaluated for potential Mh infection. mNGS enables rapid detection of pathogens that traditional methods may fail to identify. A combination of moxifloxacin and clindamycin is effective for treating PD-associated peritonitis caused by Mh.
人型支原体（Mh）是人类的一种条件致病性微生物，通常定植于成年人的泌尿生殖道并在该系统中引起感染。然而，Mh作为腹膜透析（PD）相关腹膜炎的病原体鲜有报道。
一名接受维持性PD治疗的46岁女性出现腹痛和浑浊的PD流出液。她的PD方式是持续性非卧床腹膜透析（CAPD）。PD流出液和血液培养均为阴性，经验性抗生素治疗无效，导致难治性腹膜炎的诊断。宏基因组下一代测序（mNGS）在PD流出液中检测到Mh。治疗调整为腹腔内（IP）使用克林霉素联合静脉滴注莫西沙星，结果完全康复。
对于培养阴性的PD相关腹膜炎或难治性腹膜炎患者，应评估是否存在潜在的Mh感染。mNGS能够快速检测传统方法可能无法识别的病原体。莫西沙星和克林霉素联合使用对治疗由Mh引起的PD相关腹膜炎有效。
